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Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency.
Borisova E, Nishimura K, An Y, Takami M, Li J, Song D, Matsuo-Takasaki M, Luijkx D, Aizawa S, Kuno A, Sugihara E, Sato TA, Yumoto F, Terada T, Hisatake K, Hayashi Y. Borisova E, et al. Among authors: hayashi y. iScience. 2021 Dec 14;25(1):103525. doi: 10.1016/j.isci.2021.103525. eCollection 2022 Jan 21. iScience. 2021. PMID: 35106457 Free PMC article.
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick RJ. Hayashi Y, et al. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4666-71. doi: 10.1073/pnas.1502855112. Epub 2015 Mar 30. Proc Natl Acad Sci U S A. 2015. PMID: 25825768 Free PMC article.
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.
Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S. Hayashi Y, et al. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13057-13062. doi: 10.1073/pnas.1603668113. Epub 2016 Oct 28. Proc Natl Acad Sci U S A. 2016. PMID: 27794120 Free PMC article.
A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation.
Nishimura K, Aizawa S, Nugroho FL, Shiomitsu E, Tran YTH, Bui PL, Borisova E, Sakuragi Y, Takada H, Kurisaki A, Hayashi Y, Fukuda A, Nakanishi M, Hisatake K. Nishimura K, et al. Among authors: hayashi y. Stem Cell Reports. 2017 Mar 14;8(3):787-801. doi: 10.1016/j.stemcr.2017.01.026. Epub 2017 Mar 2. Stem Cell Reports. 2017. PMID: 28262547 Free PMC article.
Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming.
Bui PL, Nishimura K, Seminario Mondejar G, Kumar A, Aizawa S, Murano K, Nagata K, Hayashi Y, Fukuda A, Onuma Y, Ito Y, Nakanishi M, Hisatake K. Bui PL, et al. Among authors: hayashi y. Cell Rep. 2019 Nov 12;29(7):1909-1922.e5. doi: 10.1016/j.celrep.2019.10.010. Cell Rep. 2019. PMID: 31722206 Free article.
Generation of two human induced pluripotent stem cell lines derived from two juvenile nephronophthisis patients with NPHP1 deletion.
Arai Y, Takami M, An Y, Matsuo-Takasaki M, Hemmi Y, Wakabayashi T, Inoue J, Noguchi M, Nakamura Y, Sugimoto K, Takemura T, Okita K, Osafune K, Takasato M, Hayata T, Hayashi Y. Arai Y, et al. Among authors: hayashi y. Stem Cell Res. 2020 May;45:101815. doi: 10.1016/j.scr.2020.101815. Epub 2020 Apr 21. Stem Cell Res. 2020. PMID: 32361464 Free article.
8,086 results