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Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors.
Stickdorn J, Stein L, Arnold-Schild D, Hahlbrock J, Medina-Montano C, Bartneck J, Ziß T, Montermann E, Kappel C, Hobernik D, Haist M, Yurugi H, Raabe M, Best A, Rajalingam K, Radsak MP, David SA, Koynov K, Bros M, Grabbe S, Schild H, Nuhn L. Stickdorn J, et al. Among authors: david sa. ACS Nano. 2022 Mar 22;16(3):4426-4443. doi: 10.1021/acsnano.1c10709. Epub 2022 Feb 1. ACS Nano. 2022. PMID: 35103463 Free PMC article.
Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators.
Huppertsberg A, Kaps L, Zhong Z, Schmitt S, Stickdorn J, Deswarte K, Combes F, Czysch C, De Vrieze J, Kasmi S, Choteschovsky N, Klefenz A, Medina-Montano C, Winterwerber P, Chen C, Bros M, Lienenklaus S, Sanders NN, Koynov K, Schuppan D, Lambrecht BN, David SA, De Geest BG, Nuhn L. Huppertsberg A, et al. Among authors: david sa. J Am Chem Soc. 2021 Jul 7;143(26):9872-9883. doi: 10.1021/jacs.1c03772. Epub 2021 Jun 24. J Am Chem Soc. 2021. PMID: 34166595 Free PMC article.
Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy.
Li H, Van Herck S, Liu Y, Hao Y, Ding X, Nuhn L, Zhong Z, Combes F, Sanders NN, Lienenklaus S, Koker SD, David SA, Wang Y, De Geest BG, Zhang Z. Li H, et al. Among authors: david sa. ACS Biomater Sci Eng. 2020 Sep 14;6(9):4993-5000. doi: 10.1021/acsbiomaterials.0c00485. Epub 2020 Aug 11. ACS Biomater Sci Eng. 2020. PMID: 33455292
Lipid-Polyglutamate Nanoparticle Vaccine Platform.
Van Lysebetten D, Malfanti A, Deswarte K, Koynov K, Golba B, Ye T, Zhong Z, Kasmi S, Lamoot A, Chen Y, Van Herck S, Lambrecht BN, Sanders NN, Lienenklaus S, David SA, Vicent MJ, De Koker S, De Geest BG. Van Lysebetten D, et al. Among authors: david sa. ACS Appl Mater Interfaces. 2021 Feb 10;13(5):6011-6022. doi: 10.1021/acsami.0c20607. Epub 2021 Jan 28. ACS Appl Mater Interfaces. 2021. PMID: 33507728 Free PMC article.
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine*.
Jangra S, De Vrieze J, Choi A, Rathnasinghe R, Laghlali G, Uvyn A, Van Herck S, Nuhn L, Deswarte K, Zhong Z, Sanders NN, Lienenklaus S, David SA, Strohmeier S, Amanat F, Krammer F, Hammad H, Lambrecht BN, Coughlan L, García-Sastre A, De Geest BG, Schotsaert M. Jangra S, et al. Among authors: david sa. Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9467-9473. doi: 10.1002/anie.202015362. Epub 2021 Mar 11. Angew Chem Int Ed Engl. 2021. PMID: 33464672 Free PMC article.
Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists.
De Vrieze J, Louage B, Deswarte K, Zhong Z, De Coen R, Van Herck S, Nuhn L, Kaas Frich C, Zelikin AN, Lienenklaus S, Sanders NN, Lambrecht BN, David SA, De Geest BG. De Vrieze J, et al. Among authors: david sa. Angew Chem Int Ed Engl. 2019 Oct 21;58(43):15390-15395. doi: 10.1002/anie.201905687. Epub 2019 Sep 12. Angew Chem Int Ed Engl. 2019. PMID: 31397948
119 results