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Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19.
Fier PS, Xu Y, Poirier M, Brito G, Zheng M, Bade R, Sirota E, Stone K, Tan L, Humphrey GR, Chang D, Bothe J, Zhang Y, Bernardoni F, Castro S, Zompa MA, Taylor J, Sirk KM, Diaz-Santana A, Diribe I, Emerson KM, Krishnamurthi B, Zhao R, Ward M, Xiao C, Ouyand H, Zhan J, Morris WJ. Fier PS, et al. Among authors: morris wj. Org Process Res Dev. 2021 Dec 17;25(12):2806-2815. doi: 10.1021/acs.oprd.1c00400. Epub 2021 Dec 10. Org Process Res Dev. 2021. PMID: 35095257 Review.
A Next Generation Synthesis of BACE1 Inhibitor Verubecestat (MK-8931).
Thaisrivongs DA, Morris WJ, Tan L, Song ZJ, Lyons TW, Waldman JH, Naber JR, Chen W, Chen L, Zhang B, Yang J. Thaisrivongs DA, et al. Among authors: morris wj. Org Lett. 2018 Mar 16;20(6):1568-1571. doi: 10.1021/acs.orglett.8b00259. Epub 2018 Feb 26. Org Lett. 2018. PMID: 29481097
Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor.
Zhong YL, Cleator E, Liu Z, Yin J, Morris WJ, Alam M, Bishop B, Dumas AM, Edwards J, Goodyear A, Mullens P, Song ZJ, Shevlin M, Thaisrivongs DA, Li H, Sherer EC, Cohen RD, Yin J, Tan L, Yasuda N, Limanto J, Davies A, Campos KR. Zhong YL, et al. Among authors: morris wj. J Org Chem. 2019 Apr 19;84(8):4780-4795. doi: 10.1021/acs.joc.8b02500. Epub 2018 Dec 10. J Org Chem. 2019. PMID: 30475616
Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19.
McIntosh JA, Benkovics T, Silverman SM, Huffman MA, Kong J, Maligres PE, Itoh T, Yang H, Verma D, Pan W, Ho HI, Vroom J, Knight AM, Hurtak JA, Klapars A, Fryszkowska A, Morris WJ, Strotman NA, Murphy GS, Maloney KM, Fier PS. McIntosh JA, et al. Among authors: morris wj. ACS Cent Sci. 2021 Dec 22;7(12):1980-1985. doi: 10.1021/acscentsci.1c00608. Epub 2021 Oct 29. ACS Cent Sci. 2021. PMID: 34963891 Free PMC article.
Synthesis of the γ-Secretase Modulator MK-8428.
Miller SP, Morris WJ, Orr RK, Eckert J, Milan J, Maust M, Cowden C, Cui J. Miller SP, et al. Among authors: morris wj. J Org Chem. 2017 Mar 17;82(6):2957-2964. doi: 10.1021/acs.joc.6b02979. Epub 2017 Mar 6. J Org Chem. 2017. PMID: 28262021
Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors.
Bungard CJ, Williams PD, Schulz J, Wiscount CM, Holloway MK, Loughran HM, Manikowski JJ, Su HP, Bennett DJ, Chang L, Chu XJ, Crespo A, Dwyer MP, Keertikar K, Morriello GJ, Stamford AW, Waddell ST, Zhong B, Hu B, Ji T, Diamond TL, Bahnck-Teets C, Carroll SS, Fay JF, Min X, Morris W, Ballard JE, Miller MD, McCauley JA. Bungard CJ, et al. ACS Med Chem Lett. 2017 Nov 13;8(12):1292-1297. doi: 10.1021/acsmedchemlett.7b00386. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259750 Free PMC article.
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.
Cheung-Lee WL, Kolev JN, McIntosh JA, Gil AA, Pan W, Xiao L, Velásquez JE, Gangam R, Winston MS, Li S, Abe K, Alwedi E, Dance ZEX, Fan H, Hiraga K, Kim J, Kosjek B, Le DN, Marzijarani NS, Mattern K, McMullen JP, Narsimhan K, Vikram A, Wang W, Yan JX, Yang RS, Zhang V, Zhong W, DiRocco DA, Morris WJ, Murphy GS, Maloney KM. Cheung-Lee WL, et al. Among authors: morris wj. Angew Chem Int Ed Engl. 2024 Mar 22;63(13):e202316133. doi: 10.1002/anie.202316133. Epub 2024 Feb 19. Angew Chem Int Ed Engl. 2024. PMID: 38279624
146 results