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Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19.
Fier PS, Xu Y, Poirier M, Brito G, Zheng M, Bade R, Sirota E, Stone K, Tan L, Humphrey GR, Chang D, Bothe J, Zhang Y, Bernardoni F, Castro S, Zompa MA, Taylor J, Sirk KM, Diaz-Santana A, Diribe I, Emerson KM, Krishnamurthi B, Zhao R, Ward M, Xiao C, Ouyand H, Zhan J, Morris WJ. Fier PS, et al. Among authors: bothe j. Org Process Res Dev. 2021 Dec 17;25(12):2806-2815. doi: 10.1021/acs.oprd.1c00400. Epub 2021 Dec 10. Org Process Res Dev. 2021. PMID: 35095257 Review.
Discovery and Control of Succinimide Formation and Accumulation at Aspartic Acid Residues in The Complementarity-Determining Region of a Therapeutic Monoclonal Antibody.
VanAernum ZL, Sergi JA, Dey M, Toner T, Kilgore B, Lay-Fortenbery A, Wang Y, Bian S, Kochert BA, Bothe JR, Gao X, Richardson D, Schuessler HA. VanAernum ZL, et al. Among authors: bothe jr. Pharm Res. 2023 Jun;40(6):1411-1423. doi: 10.1007/s11095-022-03462-0. Epub 2023 Jan 10. Pharm Res. 2023. PMID: 36627449
New and Evolving Techniques for the Characterization of Peptide Therapeutics.
D'Addio SM, Bothe JR, Neri C, Walsh PL, Zhang J, Pierson E, Mao Y, Gindy M, Leone A, Templeton AC. D'Addio SM, et al. Among authors: bothe jr. J Pharm Sci. 2016 Oct;105(10):2989-3006. doi: 10.1016/j.xphs.2016.06.011. Epub 2016 Aug 4. J Pharm Sci. 2016. PMID: 27499338 Review.
Coated microneedles for transdermal delivery of a potent pharmaceutical peptide.
Kapoor Y, Milewski M, Dick L, Zhang J, Bothe JR, Gehrt M, Manser K, Nissley B, Petrescu I, Johnson P, Burton S, Moseman J, Hua V, Grunewald T, Tomai M, Smith R. Kapoor Y, et al. Among authors: bothe jr. Biomed Microdevices. 2019 Dec 16;22(1):7. doi: 10.1007/s10544-019-0462-1. Biomed Microdevices. 2019. PMID: 31845070
36 results