In Vitro and In Vivo Investigations of Chromone Derivatives as Potential Multitarget-Directed Ligands: Cognitive Amelioration Utilizing a Scopolamine-Induced Zebrafish Model.
Kumar N, Jangid K, Kumar V, Yadav RP, Mishra J, Upadhayay S, Kumar V, Devi B, Kumar V, Dwivedi AR, Kumar P, Baranwal S, Bhatti JS, Kumar V.
Kumar N, et al.
ACS Chem Neurosci. 2024 May 25. doi: 10.1021/acschemneuro.4c00007. Online ahead of print.
ACS Chem Neurosci. 2024.
PMID: 38795037
The synthesized compounds exhibited multipotent activity against AChE, BuChE, MAO-B, and amyloid beta aggregation. Three potent compounds, i.e., VN-3, VN-14, and VN-19 were identified that displayed remarkable activities against different targets. ...Compound VN-19 …
The synthesized compounds exhibited multipotent activity against AChE, BuChE, MAO-B, and amyloid beta aggregation. Three poten …