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In Vitro and In Vivo Investigations of Chromone Derivatives as Potential Multitarget-Directed Ligands: Cognitive Amelioration Utilizing a Scopolamine-Induced Zebrafish Model.
Kumar N, Jangid K, Kumar V, Yadav RP, Mishra J, Upadhayay S, Kumar V, Devi B, Kumar V, Dwivedi AR, Kumar P, Baranwal S, Bhatti JS, Kumar V. Kumar N, et al. ACS Chem Neurosci. 2024 May 25. doi: 10.1021/acschemneuro.4c00007. Online ahead of print. ACS Chem Neurosci. 2024. PMID: 38795037
The synthesized compounds exhibited multipotent activity against AChE, BuChE, MAO-B, and amyloid beta aggregation. Three potent compounds, i.e., VN-3, VN-14, and VN-19 were identified that displayed remarkable activities against different targets. ...Compound VN-19 …
The synthesized compounds exhibited multipotent activity against AChE, BuChE, MAO-B, and amyloid beta aggregation. Three poten …
Development of scoring-assisted generative exploration (SAGE) and its application to dual inhibitor design for acetylcholinesterase and monoamine oxidase B.
Lim H. Lim H. J Cheminform. 2024 May 24;16(1):59. doi: 10.1186/s13321-024-00845-w. J Cheminform. 2024. PMID: 38790018
Furthermore, I suggested a top-ranked molecule with SAGE as dual inhibitors of acetylcholinesterase and monoamine oxidase B through multiple desired property optimization. ...Additionally, the application of SAGE to discover dual inhibitors for acetylcholinesterase …
Furthermore, I suggested a top-ranked molecule with SAGE as dual inhibitors of acetylcholinesterase and monoamine oxidase B th …
Safinamide as adjunctive therapy to levodopa monotherapy for patients with Parkinson's disease with wearing-off: The Japanese observational J-SILVER study.
Nishikawa N, Hatano T, Nishioka K, Ueno SI, Saiki S, Nakamura R, Yoritaka A, Ogawa T, Shimo Y, Sako W, Shimura H, Furukawa Y, Kamei T, Ishida T, Hattori N; J-SILVER study group. Nishikawa N, et al. J Neurol Sci. 2024 May 17;461:123051. doi: 10.1016/j.jns.2024.123051. Online ahead of print. J Neurol Sci. 2024. PMID: 38788287
Role of Vasoactive Hormone-Induced Signal Transduction in Cardiac Hypertrophy and Heart Failure.
Dhalla NS, Mota KO, Elimban V, Shah AK, de Vasconcelos CML, Bhullar SK. Dhalla NS, et al. Cells. 2024 May 17;13(10):856. doi: 10.3390/cells13100856. Cells. 2024. PMID: 38786079 Free PMC article. Review.
The prolonged exposure of the hypertrophied heart to these vasoactive hormones has been reported to result in the oxidation of catecholamines and serotonin via monoamine oxidase as well as the activation of NADPH oxidase via angiotensin II and endothelins to …
The prolonged exposure of the hypertrophied heart to these vasoactive hormones has been reported to result in the oxidation of catecholamine …
Recent Advancements and SAR Studies of Synthetic Coumarins as MAO-B Inhibitors: An Updated Review.
Kaur P, Rangra NK. Kaur P, et al. Mini Rev Med Chem. 2024 May 20. doi: 10.2174/0113895575290599240503080025. Online ahead of print. Mini Rev Med Chem. 2024. PMID: 38778598
RESULTS: The results revealed the updated review on SAR studies of synthetic coumarins as MAO-B inhibitors, specifically for Alzheimer's Disease and Parkinson's Disease. ...Numerous studies have demonstrated that chemically produced and naturally occurring coumarin …
RESULTS: The results revealed the updated review on SAR studies of synthetic coumarins as MAO-B inhibitors, specifically for A …
Construction of Multi-enzyme Integrated Catalysts for Deracemization of Cyclic Chiral Amines.
Zhou L, Li C, Dong L, Liu Y, He Y, Liu G, Bai J, Ma L, Jiang Y. Zhou L, et al. Chembiochem. 2024 May 22:e202400346. doi: 10.1002/cbic.202400346. Online ahead of print. Chembiochem. 2024. PMID: 38775416
In this research, we designed a four-enzyme integrated catalyst and used it to catalyse the racemization reaction of cyclic chiral amines, where monoamine oxidase (MAO) catalyses the selective oxidation of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MTQ), imine reducta …
In this research, we designed a four-enzyme integrated catalyst and used it to catalyse the racemization reaction of cyclic chiral amines, w …
5,7-dihydroxy-3',4',5'-trimethoxyflavone mitigates lead induced neurotoxicity in rats via its chelating, antioxidant, anti-inflammatory and monoaminergic properties.
Singh V, Shri R, Sood P, Singh M, Singh TG, Singh R, Kumar A, Ahmad SF. Singh V, et al. Food Chem Toxicol. 2024 May 18;189:114747. doi: 10.1016/j.fct.2024.114747. Online ahead of print. Food Chem Toxicol. 2024. PMID: 38768937
Cognitive and motor functions were assessed using Morris Water Maze and horizontal bar tests. Lead, monoamine oxidase (MAO) A and B enzymes, reduced glutathione (GSH), thiobarbituric acid reactive species (TBARS), Tumor necrosis factor-alpha (TNF-alpha), and IL-6 le …
Cognitive and motor functions were assessed using Morris Water Maze and horizontal bar tests. Lead, monoamine oxidase (MAO) A …
27,002 results
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