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Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer.
Van den Broeck T, Moris L, Gevaert T, Davicioni E, Boeckx B, Lambrechts D, Helsen C, Handle F, Ghesquière B, Soenen S, Smeets E, Eerlings R, El Kharraz S, Devlies W, Karnes RJ, Lotan T, Van Poppel H, Joniau S, Claessens F. Van den Broeck T, et al. Among authors: eerlings r. Mol Cancer Res. 2022 Apr 1;20(4):527-541. doi: 10.1158/1541-7786.MCR-21-0388. Mol Cancer Res. 2022. PMID: 35082164
Drivers of AR indifferent anti-androgen resistance in prostate cancer cells.
Handle F, Prekovic S, Helsen C, Van den Broeck T, Smeets E, Moris L, Eerlings R, Kharraz SE, Urbanucci A, Mills IG, Joniau S, Attard G, Claessens F. Handle F, et al. Among authors: eerlings r. Sci Rep. 2019 Sep 24;9(1):13786. doi: 10.1038/s41598-019-50220-1. Sci Rep. 2019. PMID: 31551480 Free PMC article.
A disease-associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer.
Smeets E, Huang S, Lee XY, Van Nieuwenhove E, Helsen C, Handle F, Moris L, El Kharraz S, Eerlings R, Devlies W, Willemsen M, Bücken L, Prezzemolo T, Humblet-Baron S, Voet A, Rochtus A, Van Schepdael A, de Zegher F, Claessens F. Smeets E, et al. Among authors: eerlings r. J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2242-2253. doi: 10.1002/jcsm.13022. Epub 2022 Jun 9. J Cachexia Sarcopenia Muscle. 2022. PMID: 35686338 Free PMC article.
The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation.
El Kharraz S, Dubois V, van Royen ME, Houtsmuller AB, Pavlova E, Atanassova N, Nguyen T, Voet A, Eerlings R, Handle F, Prekovic S, Smeets E, Moris L, Devlies W, Ohlsson C, Poutanen M, Verstrepen KJ, Carmeliet G, Launonen KM, Helminen L, Palvimo JJ, Libert C, Vanderschueren D, Helsen C, Claessens F. El Kharraz S, et al. Among authors: eerlings r. EMBO Rep. 2021 Dec 6;22(12):e52764. doi: 10.15252/embr.202152764. Epub 2021 Oct 18. EMBO Rep. 2021. PMID: 34661369 Free PMC article.
Rational evolution for altering the ligand preference of estrogen receptor alpha.
Eerlings R, Gupta P, Lee XY, Nguyen T, El Kharraz S, Handle F, Smeets E, Moris L, Devlies W, Vandewinkel B, Thiry I, Ta DT, Gorkovskiy A, Voordeckers K, Henckaerts E, Pinheiro VB, Claessens F, Verstrepen KJ, Voet A, Helsen C. Eerlings R, et al. Protein Sci. 2024 Apr;33(4):e4940. doi: 10.1002/pro.4940. Protein Sci. 2024. PMID: 38511482
Study of novel androgen receptor V770 variant in androgen insensitivity syndrome patients reveals the transitional state of the androgen receptor ligand binding domain homodimer.
Helsen C, Rocca MS, Nguyen TT, Eerlings R, Lee XY, De Block S, Vinanzi C, Di Millo F, Giagulli V, Voet A, Ferlin A, Claessens F. Helsen C, et al. Among authors: eerlings r. Protein Sci. 2023 Apr;32(4):e4599. doi: 10.1002/pro.4599. Protein Sci. 2023. PMID: 36806291 Free PMC article.