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Disruption of DNA Repair and Survival Pathways through Heat Shock Protein Inhibition by Onalespib to Sensitize Malignant Gliomas to Chemoradiation Therapy.
Xu J, Wu PJ, Lai TH, Sharma P, Canella A, Welker AM, Beattie CE, Elder JB, Easley M, Lonser R, Jacob NK, Pietrzak M, Timmers CM, Lang F, Sampath D, Puduvalli VK. Xu J, et al. Among authors: beattie ce. Clin Cancer Res. 2022 May 2;28(9):1979-1990. doi: 10.1158/1078-0432.CCR-20-0468. Clin Cancer Res. 2022. PMID: 35140124 Free PMC article.
ΔNp73/ETS2 complex drives glioblastoma pathogenesis- targeting downstream mediators by rebastinib prolongs survival in preclinical models of glioblastoma.
Cam M, Charan M, Welker AM, Dravid P, Studebaker AW, Leonard JR, Pierson CR, Nakano I, Beattie CE, Hwang EI, Kambhampati M, Nazarian J, Finlay JL, Cam H. Cam M, et al. Among authors: beattie ce. Neuro Oncol. 2020 Mar 5;22(3):345-356. doi: 10.1093/neuonc/noz190. Neuro Oncol. 2020. PMID: 31763674 Free PMC article.
PRMT5 as a druggable target for glioblastoma therapy.
Banasavadi-Siddegowda YK, Welker AM, An M, Yang X, Zhou W, Shi G, Imitola J, Li C, Hsu S, Wang J, Phelps M, Zhang J, Beattie CE, Baiocchi R, Kaur B. Banasavadi-Siddegowda YK, et al. Among authors: beattie ce. Neuro Oncol. 2018 May 18;20(6):753-763. doi: 10.1093/neuonc/nox206. Neuro Oncol. 2018. PMID: 29106602 Free PMC article.
Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant Gliomas.
Canella A, Welker AM, Yoo JY, Xu J, Abas FS, Kesanakurti D, Nagarajan P, Beattie CE, Sulman EP, Liu J, Gumin J, Lang FF, Gurcan MN, Kaur B, Sampath D, Puduvalli VK. Canella A, et al. Among authors: beattie ce. Clin Cancer Res. 2017 Oct 15;23(20):6215-6226. doi: 10.1158/1078-0432.CCR-16-3151. Epub 2017 Jul 5. Clin Cancer Res. 2017. PMID: 28679777 Free PMC article.
63 results