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Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death.
Margreiter MA, Witzenberger M, Wasser Y, Davydova E, Janowski R, Metz J, Habib P, Sahnoun SEM, Sobisch C, Poma B, Palomino-Hernandez O, Wagner M, Carell T, Jon Shah N, Schulz JB, Niessing D, Voigt A, Rossetti G. Margreiter MA, et al. Among authors: schulz jb. Comput Struct Biotechnol J. 2021 Dec 28;20:443-458. doi: 10.1016/j.csbj.2021.12.029. eCollection 2022. Comput Struct Biotechnol J. 2021. PMID: 35070167 Free PMC article.
TDP-43-mediated neuron loss in vivo requires RNA-binding activity.
Voigt A, Herholz D, Fiesel FC, Kaur K, Müller D, Karsten P, Weber SS, Kahle PJ, Marquardt T, Schulz JB. Voigt A, et al. Among authors: schulz jb. PLoS One. 2010 Aug 18;5(8):e12247. doi: 10.1371/journal.pone.0012247. PLoS One. 2010. PMID: 20806063 Free PMC article.
The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.
Butler EK, Voigt A, Lutz AK, Toegel JP, Gerhardt E, Karsten P, Falkenburger B, Reinartz A, Winklhofer KF, Schulz JB. Butler EK, et al. Among authors: schulz jb. PLoS Genet. 2012 Feb;8(2):e1002488. doi: 10.1371/journal.pgen.1002488. Epub 2012 Feb 2. PLoS Genet. 2012. PMID: 22319455 Free PMC article.
TRAP1 rescues PINK1 loss-of-function phenotypes.
Zhang L, Karsten P, Hamm S, Pogson JH, Müller-Rischart AK, Exner N, Haass C, Whitworth AJ, Winklhofer KF, Schulz JB, Voigt A. Zhang L, et al. Among authors: schulz jb. Hum Mol Genet. 2013 Jul 15;22(14):2829-41. doi: 10.1093/hmg/ddt132. Epub 2013 Mar 21. Hum Mol Genet. 2013. PMID: 23525905 Free PMC article.
CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration.
Liman J, Deeg S, Voigt A, Voßfeldt H, Dohm CP, Karch A, Weishaupt J, Schulz JB, Bähr M, Kermer P. Liman J, et al. Among authors: schulz jb. J Neurochem. 2014 Jun;129(6):1013-23. doi: 10.1111/jnc.12684. Epub 2014 Mar 24. J Neurochem. 2014. PMID: 24548080 Free article.
477 results