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Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders.
Peters S, Wirkert E, Kuespert S, Heydn R, Johannesen S, Friedrich A, Mailänder S, Korte S, Mecklenburg L, Aigner L, Bruun TH, Bogdahn U. Peters S, et al. Among authors: friedrich a. Pharmaceutics. 2022 Jan 15;14(1):200. doi: 10.3390/pharmaceutics14010200. Pharmaceutics. 2022. PMID: 35057094 Free PMC article.
Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells.
Neuwahl J, Neumann CA, Fitz AC, Biermann AD, Magel M, Friedrich A, Sellin L, Stork B, Piekorz RP, Proksch P, Budach W, Jänicke RU, Sohn D. Neuwahl J, et al. Among authors: friedrich a. Cell Death Dis. 2024 May 29;15(5):373. doi: 10.1038/s41419-024-06755-x. Cell Death Dis. 2024. PMID: 38811535 Free PMC article.
Species-wide quantitative transcriptomes and proteomes reveal distinct genetic control of gene expression variation in yeast.
Teyssonnière EM, Trébulle P, Muenzner J, Loegler V, Ludwig D, Amari F, Mülleder M, Friedrich A, Hou J, Ralser M, Schacherer J. Teyssonnière EM, et al. Among authors: friedrich a. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2319211121. doi: 10.1073/pnas.2319211121. Epub 2024 May 2. Proc Natl Acad Sci U S A. 2024. PMID: 38696467 Free PMC article.
Phosphine-catalyzed 1,2-cis-diboration of 1,3-butadiynes.
Li W, Ricker R, Lok Chan K, Fung Lau P, Buchbinder NW, Krebs J, Friedrich A, Lin Z, Santos WL, Radius U, Marder TB. Li W, et al. Among authors: friedrich a. Chemistry. 2024 Apr 9:e202401235. doi: 10.1002/chem.202401235. Online ahead of print. Chemistry. 2024. PMID: 38593362
Tumor-associated macrophages impair NK cell IFN-γ production and contribute to tumor progression in clear cell renal cell carcinoma.
Núñez SY, Trotta A, Regge MV, Amarilla MS, Secchiari F, Sierra JM, Santilli MC, Gantov M, Rovegno A, Richards N, Ameri C, Ríos Pita H, Rico L, Mieggi M, Vitagliano G, Blas L, Friedrich AD, Domaica CI, Fuertes MB, Zwirner NW. Núñez SY, et al. Among authors: friedrich ad. Eur J Immunol. 2024 Apr 6:e2350878. doi: 10.1002/eji.202350878. Online ahead of print. Eur J Immunol. 2024. PMID: 38581345
800 results