Simoes S - Search Results

1

The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease.

Qureshi YH, Berman DE, Marsh SE, Klein RL, Patel VM, Simoes S, Kannan S, Petsko GA, Stevens B, Small SA. Qureshi YH, et al. Among authors: simoes s. Cell Rep. 2022 Jan 18;38(3):110262. doi: 10.1016/j.celrep.2021.110262. Cell Rep. 2022. PMID: 35045281 Free PMC article.

2

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system.

Morel E, Chamoun Z, Lasiecka ZM, Chan RB, Williamson RL, Vetanovetz C, Dall'Armi C, Simoes S, Point Du Jour KS, McCabe BD, Small SA, Di Paolo G. Morel E, et al. Among authors: simoes s. Nat Commun. 2013;4:2250. doi: 10.1038/ncomms3250. Nat Commun. 2013. PMID: 23907271 Free PMC article.

3

Pharmacological chaperones stabilize retromer to limit APP processing.

Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. Mecozzi VJ, et al. Among authors: simoes s. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20. Nat Chem Biol. 2014. PMID: 24747528 Free PMC article.

4

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures.

Miranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G. Miranda AM, et al. Among authors: simoes s. Nat Commun. 2018 Jan 18;9(1):291. doi: 10.1038/s41467-017-02533-w. Nat Commun. 2018. PMID: 29348617 Free PMC article.

5

Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans.

Simoes S, Neufeld JL, Triana-Baltzer G, Moughadam S, Chen EI, Kothiya M, Qureshi YH, Patel V, Honig LS, Kolb H, Small SA. Simoes S, et al. Sci Transl Med. 2020 Nov 25;12(571):eaba6334. doi: 10.1126/scitranslmed.aba6334. Sci Transl Med. 2020. PMID: 33239387 Free PMC article.

6

Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling.

Simoes S, Guo J, Buitrago L, Qureshi YH, Feng X, Kothiya M, Cortes E, Patel V, Kannan S, Kim YH, Chang KT; Alzheimer's Disease Neuroimaging Initiative; Hussaini SA, Moreno H, Di Paolo G, Andersen OM, Small SA. Simoes S, et al. Cell Rep. 2021 Dec 28;37(13):110182. doi: 10.1016/j.celrep.2021.110182. Cell Rep. 2021. PMID: 34965419 Free PMC article.

7

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons.

Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H, Steinberg JI, Margittai M, Kayed R, Zurzolo C, Di Paolo G, Duff KE. Wu JW, et al. Among authors: simoes s. J Biol Chem. 2013 Jan 18;288(3):1856-70. doi: 10.1074/jbc.M112.394528. Epub 2012 Nov 27. J Biol Chem. 2013. PMID: 23188818 Free PMC article.

8

Cerebrovascular disease promotes tau pathology in Alzheimer's disease.

Laing KK, Simoes S, Baena-Caldas GP, Lao PJ, Kothiya M, Igwe KC, Chesebro AG, Houck AL, Pedraza L, Hernández AI, Li J, Zimmerman ME, Luchsinger JA, Barone FC, Moreno H, Brickman AM; Alzheimer’s Disease Neuroimaging Initiative. Laing KK, et al. Among authors: simoes s. Brain Commun. 2020 Aug 19;2(2):fcaa132. doi: 10.1093/braincomms/fcaa132. eCollection 2020. Brain Commun. 2020. PMID: 33215083 Free PMC article.

9

Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkers.

Herman M, Randall GW, Spiegel JL, Maldonado DJ, Simoes S. Herman M, et al. Among authors: simoes s. Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220387. doi: 10.1098/rstb.2022.0387. Epub 2024 Feb 19. Philos Trans R Soc Lond B Biol Sci. 2024. PMID: 38368936 Free PMC article. Review.

10

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.

van Niel G, Charrin S, Simoes S, Romao M, Rochin L, Saftig P, Marks MS, Rubinstein E, Raposo G. van Niel G, et al. Among authors: simoes s. Dev Cell. 2011 Oct 18;21(4):708-21. doi: 10.1016/j.devcel.2011.08.019. Epub 2011 Sep 29. Dev Cell. 2011. PMID: 21962903 Free PMC article.

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