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An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery.
Guo Y, Ji S, Wang W, Wong S, Yen CW, Hu C, Leung DH, Plise E, Zhang S, Zhang C, Anene UA, Zhang D, Cunningham CN, Khojasteh SC, Su D. Guo Y, et al. Among authors: zhang s, zhang c, zhang d. Anal Chem. 2022 Feb 1;94(4):2032-2041. doi: 10.1021/acs.analchem.1c04008. Epub 2022 Jan 18. Anal Chem. 2022. PMID: 35041378
Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor.
Wong H, Chen JZ, Chou B, Halladay JS, Kenny JR, La H, Marsters JC Jr, Plise E, Rudewicz PJ, Robarge K, Shin Y, Wong S, Zhang C, Khojasteh SC. Wong H, et al. Among authors: zhang c. Xenobiotica. 2009 Nov;39(11):850-61. doi: 10.3109/00498250903180289. Xenobiotica. 2009. PMID: 19845436
Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Zhang D, Le H, Cruz-Chuh JD, Bobba S, Guo J, Staben L, Zhang C, Ma Y, Kozak KR, Lewis Phillips GD, Vollmar BS, Sadowsky JD, Vandlen R, Wei B, Su D, Fan P, Dragovich PS, Khojasteh SC, Hop CECA, Pillow TH. Zhang D, et al. Among authors: zhang c. Bioconjug Chem. 2018 Feb 21;29(2):267-274. doi: 10.1021/acs.bioconjchem.7b00576. Epub 2018 Feb 7. Bioconjug Chem. 2018. PMID: 29369629
A Novel Depurination Methodology to Assess DNA Alkylation of Chloro-Bis-Seco-Cyclopropylbenzoindoles Allowed for Comparison of Minor-Groove Reactivity.
Wang S, Chen B, Dragovich P, Pillow T, Staben L, Guo J, Su D, Zhang C, Bobba S, Ma Y, Wang J, Sangaraju D, Wei B, Phillips GL, Khojasteh C, Zhang D. Wang S, et al. Among authors: zhang c, zhang d. Drug Metab Dispos. 2019 May;47(5):547-555. doi: 10.1124/dmd.118.085209. Epub 2019 Mar 11. Drug Metab Dispos. 2019. PMID: 30858239
Strategies to Mitigate the Bioactivation of Aryl Amines.
Zhang C, Crawford JJ, Landry ML, Chen H, Kenny JR, Khojasteh SC, Lee W, Ma S, Young WB. Zhang C, et al. Chem Res Toxicol. 2020 Jul 20;33(7):1950-1959. doi: 10.1021/acs.chemrestox.0c00138. Epub 2020 Jun 23. Chem Res Toxicol. 2020. PMID: 32508087
69,133 results
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