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HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation.
Dulmovits BM, Tang Y, Papoin J, He M, Li J, Yang H, Addorisio ME, Kennedy L, Khan M, Brindley E, Ashley RJ, Ackert-Bicknell C, Hale J, Kurita R, Nakamura Y, Diamond B, Barnes BJ, Hermine O, Gallagher PG, Steiner LA, Lipton JM, Taylor N, Mohandas N, Andersson U, Al-Abed Y, Tracey KJ, Blanc L. Dulmovits BM, et al. Among authors: barnes bj. Blood. 2022 May 26;139(21):3181-3193. doi: 10.1182/blood.2021012048. Blood. 2022. PMID: 35040907 Free PMC article.
Inhibition of IRF5 hyperactivation protects from lupus onset and severity.
Song S, De S, Nelson V, Chopra S, LaPan M, Kampta K, Sun S, He M, Thompson CD, Li D, Shih T, Tan N, Al-Abed Y, Capitle E, Aranow C, Mackay M, Clapp WL, Barnes BJ. Song S, et al. Among authors: barnes bj. J Clin Invest. 2020 Dec 1;130(12):6700-6717. doi: 10.1172/JCI120288. J Clin Invest. 2020. PMID: 32897883 Free PMC article. Clinical Trial.
Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis.
Romano L, Seu KG, Papoin J, Muench DE, Konstantinidis D, Olsson A, Schlum K, Chetal K, Chasis JA, Mohandas N, Barnes BJ, Zheng Y, Grimes HL, Salomonis N, Blanc L, Kalfa TA. Romano L, et al. Among authors: barnes bj. Blood. 2022 Oct 6;140(14):1621-1634. doi: 10.1182/blood.2022015724. Blood. 2022. PMID: 35862735 Free PMC article.
The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial.
Winkler A, Sun W, De S, Jiao A, Sharif MN, Symanowicz PT, Athale S, Shin JH, Wang J, Jacobson BA, Ramsey SJ, Dower K, Andreyeva T, Liu H, Hegen M, Homer BL, Brodfuehrer J, Tilley M, Gilbert SA, Danto SI, Beebe JJ, Barnes BJ, Pascual V, Lin LL, Kilty I, Fleming M, Rao VR. Winkler A, et al. Among authors: barnes bj. Arthritis Rheumatol. 2021 Dec;73(12):2206-2218. doi: 10.1002/art.41953. Epub 2021 Nov 1. Arthritis Rheumatol. 2021. PMID: 34423919 Free PMC article. Clinical Trial.
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.
Sigurdsson S, Göring HH, Kristjansdottir G, Milani L, Nordmark G, Sandling JK, Eloranta ML, Feng D, Sangster-Guity N, Gunnarsson I, Svenungsson E, Sturfelt G, Jönsen A, Truedsson L, Barnes BJ, Alm G, Rönnblom L, Syvänen AC. Sigurdsson S, et al. Among authors: barnes bj. Hum Mol Genet. 2008 Mar 15;17(6):872-81. doi: 10.1093/hmg/ddm359. Epub 2007 Dec 6. Hum Mol Genet. 2008. PMID: 18063667
113 results