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Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating.
Salerno JA, Torquato T, Temerozo JR, Goto-Silva L, Karmirian K, Mendes MA, Sacramento CQ, Fintelman-Rodrigues N, Souza LRQ, Ornelas IM, Veríssimo CP, Aragão LGHS, Vitória G, Pedrosa CSG, da Silva Gomes Dias S, Cardoso Soares V, Puig-Pijuan T, Salazar V, Dariolli R, Biagi D, Furtado DR, Barreto Chiarini L, Borges HL, Bozza PT, Zaluar P Guimarães M, Souza TML, Rehen SK. Salerno JA, et al. Among authors: souza lrq. PeerJ. 2021 Dec 20;9:e12595. doi: 10.7717/peerj.12595. eCollection 2021. PeerJ. 2021. PMID: 35036128 Free PMC article.
Non-permissive SARS-CoV-2 infection in human neurospheres.
Pedrosa CDSG, Goto-Silva L, Temerozo JR, Souza LRQ, Vitória G, Ornelas IM, Karmirian K, Mendes MA, Gomes IC, Sacramento CQ, Fintelman-Rodrigues N, Cardoso Soares V, Silva Gomes Dias SD, Salerno JA, Puig-Pijuan T, Oliveira JT, Aragão LGHS, Torquato TCQ, Veríssimo C, Biagi D, Cruvinel EM, Dariolli R, Furtado DR, Borges HL, Bozza PT, Rehen S, Moreno L Souza T, Guimarães MZP. Pedrosa CDSG, et al. Among authors: souza lrq. Stem Cell Res. 2021 Jul;54:102436. doi: 10.1016/j.scr.2021.102436. Epub 2021 Jun 20. Stem Cell Res. 2021. PMID: 34186311 Free PMC article.
WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2.
Aragão LGHS, Oliveira JT, Temerozo JR, Mendes MA, Salerno JA, Pedrosa CSG, Puig-Pijuan T, Veríssimo CP, Ornelas IM, Torquato T, Vitória G, Sacramento CQ, Fintelman-Rodrigues N, da Silva Gomes Dias S, Cardoso Soares V, Souza LRQ, Karmirian K, Goto-Silva L, Biagi D, Cruvinel EM, Dariolli R, Furtado DR, Bozza PT, Borges HL, Souza TML, Guimarães MZP, Rehen SK. Aragão LGHS, et al. Among authors: souza lrq. PeerJ. 2021 Oct 8;9:e12262. doi: 10.7717/peerj.12262. eCollection 2021. PeerJ. 2021. PMID: 34707939 Free PMC article.
In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19.
Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, Da Silva APD, Dias SDSG, da Silva CDS, Ferreira AC, Mattos M, Pão CRR, de Freitas CS, Soares VC, Hoelz LVB, Fernandes TVA, Branco FSC, Bastos MM, Boechat N, Saraiva FB, Ferreira MA, Jockusch S, Wang X, Tao C, Chien M, Xie W, Patel D, Garzia A, Tuschl T, Russo JJ, Rajoli RKR, Pedrosa CSG, Vitória G, Souza LRQ, Goto-Silva L, Guimarães MZ, Rehen SK, Owen A, Bozza FA, Bou-Habib DC, Ju J, Bozza PT, Souza TML. Sacramento CQ, et al. Among authors: souza lrq. J Antimicrob Chemother. 2021 Jun 18;76(7):1874-1885. doi: 10.1093/jac/dkab072. J Antimicrob Chemother. 2021. PMID: 33880524 Free PMC article.
Non-permissive SARS-CoV-2 infection in human neurospheres.
Pedrosa CDSG, Goto-Silva L, Temerozo JR, Souza LRQ, Vitória G, Ornelas IM, Karmirian K, Mendes MA, Gomes IC, Sacramento CQ, Fintelman-Rodrigues N, Soares VC, Dias SDSG, Salerno JA, Puig-Pijuan T, Oliveira JT, Aragão LGHS, Torquato TCQ, Veríssimo C, Biagi D, Cruvinel EM, Dariolli R, Furtado DR, Borges HL, Bozza PT, Rehen S, Souza TML, Guimarães MZP. Pedrosa CDSG, et al. Among authors: souza lrq, souza tml. bioRxiv [Preprint]. 2021 Jun 17:2020.09.11.293951. doi: 10.1101/2020.09.11.293951. bioRxiv. 2021. PMID: 33052345 Free PMC article. Updated. Preprint.
Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheres.
Goto-Silva L, Martins M, Murillo JR, Souza LRQ, Vitória G, Oliveira JT, Nascimento JM, Loiola EC, Nogueira FCS, Domont GB, Guimarães MZP, Tovar-Moll F, Rehen SK, Junqueira M. Goto-Silva L, et al. Among authors: souza lrq. Biochim Biophys Acta Proteins Proteom. 2021 Aug;1869(8):140656. doi: 10.1016/j.bbapap.2021.140656. Epub 2021 Apr 20. Biochim Biophys Acta Proteins Proteom. 2021. PMID: 33857633
The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus.
Pedrosa CDSG, Souza LRQ, Gomes TA, de Lima CVF, Ledur PF, Karmirian K, Barbeito-Andres J, Costa MDN, Higa LM, Rossi ÁD, Bellio M, Tanuri A, Prata-Barbosa A, Tovar-Moll F, Garcez PP, Lara FA, Molica RJR, Rehen SK. Pedrosa CDSG, et al. Among authors: souza lrq. PLoS Negl Trop Dis. 2020 Mar 12;14(3):e0008060. doi: 10.1371/journal.pntd.0008060. eCollection 2020 Mar. PLoS Negl Trop Dis. 2020. PMID: 32163415 Free PMC article.
New tetrodotoxin analogs in Brazilian pufferfishes tissues and microbiome.
Tonon LAC, de Azevedo GPR, Monteiro AF, Bernardi DI, Gubiani JR, Ióca LP, Mattsson HK, Moreira APB, Gomes AF, Pires Junior OR, da S G Pedrosa C, Souza LRQ, Rehen SK, Thompson CC, Thompson FL, Berlinck RGS. Tonon LAC, et al. Among authors: souza lrq. Chemosphere. 2020 Mar;242:125211. doi: 10.1016/j.chemosphere.2019.125211. Epub 2019 Oct 30. Chemosphere. 2020. PMID: 31896201
Microbiome associated with the tetrodotoxin-bearing anuran Brachycephalus pitanga.
Chimetto Tonon LA, Rua C, Crnkovic CM, Bernardi DI, Pires Junior OR, Haddad CFB, Pedrosa CSG, Souza LRQ, Rehen SK, de Azevedo GPR, Thompson CC, Thompson FL, Berlinck RGS. Chimetto Tonon LA, et al. Among authors: souza lrq. Toxicon. 2021 Nov;203:139-146. doi: 10.1016/j.toxicon.2021.10.002. Epub 2021 Oct 12. Toxicon. 2021. PMID: 34653444
18 results