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Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repair.
Hibbitts AJ, Kočí Z, Kneafsey S, Matsiko A, Žilić L, Dervan A, Hinton P, Chen G, Cavanagh B, Dowling JK, McCoy CE, Buckley CT, Archibald SJ, O'Brien FJ. Hibbitts AJ, et al. Among authors: chen g. Matrix Biol. 2022 Feb;106:34-57. doi: 10.1016/j.matbio.2022.01.002. Epub 2022 Jan 13. Matrix Biol. 2022. PMID: 35032612 Free article.
Delivery of the improved BMP-2-Advanced plasmid DNA within a gene-activated scaffold accelerates mesenchymal stem cell osteogenesis and critical size defect repair.
Raftery RM, Mencía-Castaño I, Sperger S, Chen G, Cavanagh B, Feichtinger GA, Redl H, Hacobian A, O'Brien FJ. Raftery RM, et al. Among authors: chen g. J Control Release. 2018 Aug 10;283:20-31. doi: 10.1016/j.jconrel.2018.05.022. Epub 2018 May 19. J Control Release. 2018. PMID: 29782946 Free article.
Controlling the dose-dependent, synergistic and temporal effects of NGF and GDNF by encapsulation in PLGA microparticles for use in nerve guidance conduits for the repair of large peripheral nerve defects.
Lackington WA, Kočí Z, Alekseeva T, Hibbitts AJ, Kneafsey SL, Chen G, O'Brien FJ. Lackington WA, et al. Among authors: chen g. J Control Release. 2019 Jun 28;304:51-64. doi: 10.1016/j.jconrel.2019.05.001. Epub 2019 May 2. J Control Release. 2019. PMID: 31054993
Highly versatile cell-penetrating peptide loaded scaffold for efficient and localised gene delivery to multiple cell types: From development to application in tissue engineering.
Raftery RM, Walsh DP, Blokpoel Ferreras L, Mencía Castaño I, Chen G, LeMoine M, Osman G, Shakesheff KM, Dixon JE, O'Brien FJ. Raftery RM, et al. Among authors: chen g. Biomaterials. 2019 Sep;216:119277. doi: 10.1016/j.biomaterials.2019.119277. Epub 2019 Jun 13. Biomaterials. 2019. PMID: 31252371
Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing.
Sheehy EJ, Miller GJ, Amado I, Raftery RM, Chen G, Cortright K, Vazquez AG, O'Brien FJ. Sheehy EJ, et al. Among authors: chen g. J Control Release. 2021 Jun 10;334:96-105. doi: 10.1016/j.jconrel.2021.03.031. Epub 2021 Apr 1. J Control Release. 2021. PMID: 33811984 Free article.
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