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The sodium channel of human excitable cells is a target for gambierol.
Louzao MC, Cagide E, Vieytes MR, Sasaki M, Fuwa H, Yasumoto T, Botana LM. Louzao MC, et al. Among authors: fuwa h. Cell Physiol Biochem. 2006;17(5-6):257-68. doi: 10.1159/000094138. Epub 2006 Jun 20. Cell Physiol Biochem. 2006. PMID: 16791001 Free article.
Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: a structure-activity relationships study.
Pérez S, Vale C, Alonso E, Fuwa H, Sasaki M, Konno Y, Goto T, Suga Y, Vieytes MR, Botana LM. Pérez S, et al. Among authors: fuwa h. Chem Res Toxicol. 2012 Sep 17;25(9):1929-37. doi: 10.1021/tx300242m. Epub 2012 Aug 29. Chem Res Toxicol. 2012. PMID: 22894724
The parent compound gambierol and the analogues evaluated in this work share the main crucial elements for biological activity, previously described to be the C28=C29 double bond within the H ring and the unsaturated side chain [Fuwa, H., Kainuma, N., Tachiba …
The parent compound gambierol and the analogues evaluated in this work share the main crucial elements for biological activity, previously d …
Comparative cytotoxicity of gambierol versus other marine neurotoxins.
Cagide E, Louzao MC, Espiña B, Ares IR, Vieytes MR, Sasaki M, Fuwa H, Tsukano C, Konno Y, Yotsu-Yamashita M, Paquette LA, Yasumoto T, Botana LM. Cagide E, et al. Among authors: fuwa h. Chem Res Toxicol. 2011 Jun 20;24(6):835-42. doi: 10.1021/tx200038j. Epub 2011 May 4. Chem Res Toxicol. 2011. PMID: 21517028
Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications.
Alonso E, Fuwa H, Vale C, Suga Y, Goto T, Konno Y, Sasaki M, LaFerla FM, Vieytes MR, Giménez-Llort L, Botana LM. Alonso E, et al. Among authors: fuwa h. J Am Chem Soc. 2012 May 2;134(17):7467-79. doi: 10.1021/ja300565t. Epub 2012 Apr 18. J Am Chem Soc. 2012. PMID: 22475455
115 results