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Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance.
Nelson ME, Madsen S, Cooke KC, Fritzen AM, Thorius IH, Masson SWC, Carroll L, Weiss FC, Seldin MM, Potter M, Hocking SL, Fazakerley DJ, Brandon AE, Thillainadesan S, Senior AM, Cooney GJ, Stöckli J, James DE. Nelson ME, et al. Cell Metab. 2022 Feb 1;34(2):227-239.e6. doi: 10.1016/j.cmet.2021.12.013. Epub 2022 Jan 11. Cell Metab. 2022. PMID: 35021042 Free article.
Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism.
Krycer JR, Yugi K, Hirayama A, Fazakerley DJ, Quek LE, Scalzo R, Ohno S, Hodson MP, Ikeda S, Shoji F, Suzuki K, Domanova W, Parker BL, Nelson ME, Humphrey SJ, Turner N, Hoehn KL, Cooney GJ, Soga T, Kuroda S, James DE. Krycer JR, et al. Among authors: nelson me. Cell Rep. 2017 Dec 19;21(12):3536-3547. doi: 10.1016/j.celrep.2017.11.085. Cell Rep. 2017. PMID: 29262332 Free article.
A gas trapping method for high-throughput metabolic experiments.
Krycer JR, Diskin C, Nelson ME, Zeng XY, Fazakerley DJ, James DE. Krycer JR, et al. Among authors: nelson me. Biotechniques. 2018 Jan 1;64(1):27-29. doi: 10.2144/000114629. Biotechniques. 2018. PMID: 29384075 Free article.
High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.
Burchfield JG, Kebede MA, Meoli CC, Stöckli J, Whitworth PT, Wright AL, Hoffman NJ, Minard AY, Ma X, Krycer JR, Nelson ME, Tan SX, Yau B, Thomas KC, Wee NKY, Khor EC, Enriquez RF, Vissel B, Biden TJ, Baldock PA, Hoehn KL, Cantley J, Cooney GJ, James DE, Fazakerley DJ. Burchfield JG, et al. Among authors: nelson me. J Biol Chem. 2018 Apr 13;293(15):5731-5745. doi: 10.1074/jbc.RA117.000808. Epub 2018 Feb 13. J Biol Chem. 2018. PMID: 29440390 Free PMC article.
Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.
Byrne FL, Olzomer EM, Marriott GR, Quek LE, Katen A, Su J, Nelson ME, Hart-Smith G, Larance M, Sebesfi VF, Cuff J, Martyn GE, Childress E, Alexopoulos SJ, Poon IK, Faux MC, Burgess AW, Reid G, McCarroll JA, Santos WL, Quinlan KG, Turner N, Fazakerley DJ, Kumar N, Hoehn KL. Byrne FL, et al. Among authors: nelson me. Redox Biol. 2020 Jan;28:101374. doi: 10.1016/j.redox.2019.101374. Epub 2019 Nov 5. Redox Biol. 2020. PMID: 31743887 Free PMC article.
Insulin signaling requires glucose to promote lipid anabolism in adipocytes.
Krycer JR, Quek LE, Francis D, Zadoorian A, Weiss FC, Cooke KC, Nelson ME, Diaz-Vegas A, Humphrey SJ, Scalzo R, Hirayama A, Ikeda S, Shoji F, Suzuki K, Huynh K, Giles C, Varney B, Nagarajan SR, Hoy AJ, Soga T, Meikle PJ, Cooney GJ, Fazakerley DJ, James DE. Krycer JR, et al. Among authors: nelson me. J Biol Chem. 2020 Sep 18;295(38):13250-13266. doi: 10.1074/jbc.RA120.014907. Epub 2020 Jul 28. J Biol Chem. 2020. PMID: 32723868 Free PMC article.
426 results