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Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.
Xu E, Boddu R, Abdelmotilib HA, Sokratian A, Kelly K, Liu Z, Bryant N, Chandra S, Carlisle SM, Lefkowitz EJ, Harms AS, Benveniste EN, Yacoubian TA, Volpicelli-Daley LA, Standaert DG, West AB. Xu E, et al. Among authors: standaert dg. Mol Neurodegener. 2022 Jan 10;17(1):7. doi: 10.1186/s13024-021-00509-5. Mol Neurodegener. 2022. PMID: 35012605 Free PMC article.
Transcriptional dysregulation in a transgenic model of Parkinson disease.
Yacoubian TA, Cantuti-Castelvetri I, Bouzou B, Asteris G, McLean PJ, Hyman BT, Standaert DG. Yacoubian TA, et al. Among authors: standaert dg. Neurobiol Dis. 2008 Mar;29(3):515-28. doi: 10.1016/j.nbd.2007.11.008. Epub 2007 Nov 28. Neurobiol Dis. 2008. PMID: 18191405 Free PMC article.
Targets for neuroprotection in Parkinson's disease.
Yacoubian TA, Standaert DG. Yacoubian TA, et al. Among authors: standaert dg. Biochim Biophys Acta. 2009 Jul;1792(7):676-87. doi: 10.1016/j.bbadis.2008.09.009. Epub 2008 Oct 1. Biochim Biophys Acta. 2009. PMID: 18930814 Free PMC article. Review.
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu Y, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhang J. Qiao L, et al. Among authors: standaert dg. Mol Brain. 2008 Nov 21;1:17. doi: 10.1186/1756-6606-1-17. Mol Brain. 2008. PMID: 19021916 Free PMC article.
Target validation: the Parkinson disease perspective.
Standaert DG, Yacoubian TA. Standaert DG, et al. Dis Model Mech. 2010 May-Jun;3(5-6):259-62. doi: 10.1242/dmm.004192. Dis Model Mech. 2010. PMID: 20427553 Free article. No abstract available.
LRRK2 inhibition attenuates microglial inflammatory responses.
Moehle MS, Webber PJ, Tse T, Sukar N, Standaert DG, DeSilva TM, Cowell RM, West AB. Moehle MS, et al. Among authors: standaert dg. J Neurosci. 2012 Feb 1;32(5):1602-11. doi: 10.1523/JNEUROSCI.5601-11.2012. J Neurosci. 2012. PMID: 22302802 Free PMC article.
283 results