Leary SC - Search Results

1

The Energy Sensor AMPKα1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory.

Ara A, Xu A, Ahmed KA, Leary SC, Islam MF, Wu Z, Chibbar R, Xiang J. Ara A, et al. Among authors: leary sc. Int J Mol Sci. 2021 Dec 21;23(1):37. doi: 10.3390/ijms23010037. Int J Mol Sci. 2021. PMID: 35008461 Free PMC article.

2

IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia.

Xu A, Bhanumathy KK, Wu J, Ye Z, Freywald A, Leary SC, Li R, Xiang J. Xu A, et al. Among authors: leary sc. Cell Biosci. 2016 May 6;6:30. doi: 10.1186/s13578-016-0098-2. eCollection 2016. Cell Biosci. 2016. PMID: 27158441 Free PMC article.

3

Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways.

Xu A, Leary SC, Islam MF, Wu Z, Bhanumathy KK, Ara A, Chibbar R, Fleywald A, Ahmed KA, Xiang J. Xu A, et al. Among authors: leary sc. J Immunol. 2022 Jan 1;208(1):155-168. doi: 10.4049/jimmunol.2100452. Epub 2021 Dec 6. J Immunol. 2022. PMID: 34872976

4

Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.

Huang J, Leary S, Xiang J. Huang J, et al. Cell Mol Immunol. 2022 Oct;19(10):1073-1076. doi: 10.1038/s41423-022-00879-w. Epub 2022 May 19. Cell Mol Immunol. 2022. PMID: 35589987 Free PMC article. No abstract available.

5

The Critical Role of AMPKα1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1^Weak Signal-Induced T Cell Memory: An Interplay between Yin (AMPKα1) and Yang (mTORC1) Energy Sensors in T Cell Differentiation.

Ara A, Wu Z, Xu A, Ahmed KA, Leary SC, Islam MF, Chibbar R, Wu Y, Xiang J. Ara A, et al. Among authors: leary sc. Int J Mol Sci. 2022 Aug 23;23(17):9534. doi: 10.3390/ijms23179534. Int J Mol Sci. 2022. PMID: 36076931 Free PMC article.

6

Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival.

Lowden C, Boulet A, Boehler NA, Seecharran S, Rios Garcia J, Lowe NJ, Liu J, Ong JLK, Wang W, Ma L, Cheng AH, Senatore A, Monks DA, Liu BH, Leary SC, Cheng HM. Lowden C, et al. Among authors: leary sc. Cell Rep. 2021 Sep 14;36(11):109704. doi: 10.1016/j.celrep.2021.109704. Cell Rep. 2021. PMID: 34525369 Free article.

7

The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart.

Baker ZN, Jett K, Boulet A, Hossain A, Cobine PA, Kim BE, El Zawily AM, Lee L, Tibbits GF, Petris MJ, Leary SC. Baker ZN, et al. Among authors: leary sc. Hum Mol Genet. 2017 Dec 1;26(23):4617-4628. doi: 10.1093/hmg/ddx344. Hum Mol Genet. 2017. PMID: 28973536 Free PMC article.

8

COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux.

Leary SC, Cobine PA, Nishimura T, Verdijk RM, de Krijger R, de Coo R, Tarnopolsky MA, Winge DR, Shoubridge EA. Leary SC, et al. Mol Biol Cell. 2013 Mar;24(6):683-91. doi: 10.1091/mbc.E12-09-0705. Epub 2013 Jan 23. Mol Biol Cell. 2013. PMID: 23345593 Free PMC article.

9

Blue native polyacrylamide gel electrophoresis: a powerful diagnostic tool for the detection of assembly defects in the enzyme complexes of oxidative phosphorylation.

Leary SC. Leary SC. Methods Mol Biol. 2012;837:195-206. doi: 10.1007/978-1-61779-504-6_13. Methods Mol Biol. 2012. PMID: 22215549

10

Building the Cu_A site of cytochrome c oxidase: A complicated, redox-dependent process driven by a surprisingly large complement of accessory proteins.

Jett KA, Leary SC. Jett KA, et al. Among authors: leary sc. J Biol Chem. 2018 Mar 30;293(13):4644-4652. doi: 10.1074/jbc.R117.816132. Epub 2017 Sep 29. J Biol Chem. 2018. PMID: 28972150 Free PMC article. Review.

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