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Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.
Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A. Tran TT, et al. Among authors: newton hj. PLoS Pathog. 2022 Jan 10;18(1):e1010166. doi: 10.1371/journal.ppat.1010166. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35007292 Free PMC article.
Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.
Sansom FM, Riedmaier P, Newton HJ, Dunstone MA, Müller CE, Stephan H, Byres E, Beddoe T, Rossjohn J, Cowan PJ, d'Apice AJ, Robson SC, Hartland EL. Sansom FM, et al. Among authors: newton hj. J Biol Chem. 2008 May 9;283(19):12909-18. doi: 10.1074/jbc.M801006200. Epub 2008 Mar 12. J Biol Chem. 2008. PMID: 18337253 Free PMC article.
Significant role for ladC in initiation of Legionella pneumophila infection.
Newton HJ, Sansom FM, Dao J, Cazalet C, Bruggemann H, Albert-Weissenberger C, Buchrieser C, Cianciotto NP, Hartland EL. Newton HJ, et al. Infect Immun. 2008 Jul;76(7):3075-85. doi: 10.1128/IAI.00209-08. Epub 2008 Apr 21. Infect Immun. 2008. PMID: 18426879 Free PMC article.
The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.
Newton HJ, Pearson JS, Badea L, Kelly M, Lucas M, Holloway G, Wagstaff KM, Dunstone MA, Sloan J, Whisstock JC, Kaper JB, Robins-Browne RM, Jans DA, Frankel G, Phillips AD, Coulson BS, Hartland EL. Newton HJ, et al. PLoS Pathog. 2010 May 13;6(5):e1000898. doi: 10.1371/journal.ppat.1000898. PLoS Pathog. 2010. PMID: 20485572 Free PMC article.
73 results