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Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.
Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A. Tran TT, et al. Among authors: begun j. PLoS Pathog. 2022 Jan 10;18(1):e1010166. doi: 10.1371/journal.ppat.1010166. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35007292 Free PMC article.
A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and Autophagy.
Sheng YH, Giri R, Davies J, Schreiber V, Alabbas S, Movva R, He Y, Wu A, Hooper J, McWhinney B, Oancea I, Kijanka G, Hasnain S, Lucke AJ, Fairlie DP, McGuckin MA, Florin TH, Begun J. Sheng YH, et al. Among authors: begun j. Cell Mol Gastroenterol Hepatol. 2021;11(1):33-53. doi: 10.1016/j.jcmgh.2020.05.012. Epub 2020 Jun 1. Cell Mol Gastroenterol Hepatol. 2021. PMID: 32497793 Free PMC article.
Secreted NF-κB suppressive microbial metabolites modulate gut inflammation.
Giri R, Hoedt EC, Khushi S, Salim AA, Bergot AS, Schreiber V, Thomas R, McGuckin MA, Florin TH, Morrison M, Capon RJ, Ó Cuív P, Begun J. Giri R, et al. Among authors: begun j. Cell Rep. 2022 Apr 12;39(2):110646. doi: 10.1016/j.celrep.2022.110646. Cell Rep. 2022. PMID: 35417687 Free article.
MUC1-mediated Macrophage Activation Promotes Colitis-associated Colorectal Cancer via Activating the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Axis.
Sheng YH, Davies JM, Wang R, Wong KY, Giri R, Yang Y, Begun J, Florin TH, Hasnain SZ, McGuckin MA. Sheng YH, et al. Among authors: begun j. Cell Mol Gastroenterol Hepatol. 2022;14(4):789-811. doi: 10.1016/j.jcmgh.2022.06.010. Epub 2022 Jul 6. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35809803 Free PMC article.
Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism.
Oancea I, Movva R, Das I, Aguirre de Cárcer D, Schreiber V, Yang Y, Purdon A, Harrington B, Proctor M, Wang R, Sheng Y, Lobb M, Lourie R, Ó Cuív P, Duley JA, Begun J, Florin TH. Oancea I, et al. Among authors: begun j. Gut. 2017 Jan;66(1):59-69. doi: 10.1136/gutjnl-2015-310874. Epub 2016 Jul 13. Gut. 2017. PMID: 27411368 Free PMC article.
189 results