Identification of a flexible loop region (297-313) of urokinase-type plasminogen activator, which helps determine its catalytic activity.
Sun Z, Jiang Y, Ma Z, Wu H, Liu BF, Xue Y, Tang W, Chen Y, Li C, Zhu D, Gurewich V, Liu JN.
Sun Z, et al. Among authors: tang w.
J Biol Chem. 1997 Sep 19;272(38):23818-23. doi: 10.1074/jbc.272.38.23818.
J Biol Chem. 1997.
PMID: 9295329
Free article.
This was related to the loop allowing the positive charge of Lys300(c143) to transiently interact with Asp355(c194), thereby inducing an active conformation of the protease domain (Liu, J. N., Tang, W., Sun, Z., Kung, W., Pannell, R., Sarmientos, P., and Gure …
This was related to the loop allowing the positive charge of Lys300(c143) to transiently interact with Asp355(c194), thereby inducing an act …