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Oligonucleotides containing 2'-O-methyl-5-(1-phenyl-1,2,3-triazol-4-yl)uridines demonstrate increased affinity for RNA and induce exon-skipping in vitro.
Bioorg Med Chem. 2022 Feb 1;55:116559. doi: 10.1016/j.bmc.2021.116559. Epub 2021 Dec 12.
Bioorg Med Chem. 2022.
PMID: 34999527
Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro.
Raguraman P, Wang T, Ma L, Jørgensen PT, Wengel J, Veedu RN.
Raguraman P, et al.
Int J Mol Sci. 2020 Mar 31;21(7):2434. doi: 10.3390/ijms21072434.
Int J Mol Sci. 2020.
PMID: 32244535
Free PMC article.
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Phosphorothioate modification improves exon-skipping of antisense oligonucleotides based on sulfonyl phosphoramidates in mdx mouse myotubes.
Su Y, Raguraman P, Veedu RN, Filichev VV.
Su Y, et al. Among authors: raguraman p.
Org Biomol Chem. 2022 May 11;20(18):3790-3797. doi: 10.1039/d2ob00304j.
Org Biomol Chem. 2022.
PMID: 35438707
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Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer Therapeutics.
Le BT, Raguraman P, Kosbar TR, Fletcher S, Wilton SD, Veedu RN.
Le BT, et al. Among authors: raguraman p.
Mol Ther Nucleic Acids. 2019 Mar 1;14:142-157. doi: 10.1016/j.omtn.2018.11.007. Epub 2018 Nov 20.
Mol Ther Nucleic Acids. 2019.
PMID: 30594893
Free PMC article.
Review.
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Antisense Oligonucleotide-Mediated Splice Switching: Potential Therapeutic Approach for Cancer Mitigation.
Raguraman P, Balachandran AA, Chen S, Diermeier SD, Veedu RN.
Raguraman P, et al.
Cancers (Basel). 2021 Nov 5;13(21):5555. doi: 10.3390/cancers13215555.
Cancers (Basel). 2021.
PMID: 34771719
Free PMC article.
Review.
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Splice-Switching Antisense Oligonucleotides Targeting Extra- and Intracellular Domains of Epidermal Growth Factor Receptor in Cancer Cells.
Balachandran AA, Raguraman P, Rahimizadeh K, Veedu RN.
Balachandran AA, et al. Among authors: raguraman p.
Biomedicines. 2023 Dec 13;11(12):3299. doi: 10.3390/biomedicines11123299.
Biomedicines. 2023.
PMID: 38137520
Free PMC article.
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Expediting dynamics approach to understand the influence of 14-3-3ζ causing metastatic cancer through the interaction of YAP1 and β-TRCP.
D K, Ramireddy S, P R, C S.
D K, et al. Among authors: p r.
Mol Biosyst. 2017 Sep 26;13(10):1981-1992. doi: 10.1039/c7mb00271h.
Mol Biosyst. 2017.
PMID: 28745364
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