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Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin.
ACS Chem Biol. 2022 Jan 21;17(1):138-146. doi: 10.1021/acschembio.1c00799. Epub 2022 Jan 7.
ACS Chem Biol. 2022.
PMID: 34994196
Crystal structure of the α-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer.
Hsiao YH, Huang SJ, Lin EC, Hsiao PY, Toh SI, Chen IH, Xu Z, Lin YP, Liu HJ, Chang CY.
Hsiao YH, et al. Among authors: toh si.
Front Chem. 2022 Sep 13;10:1001311. doi: 10.3389/fchem.2022.1001311. eCollection 2022.
Front Chem. 2022.
PMID: 36176888
Free PMC article.
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Characterization and Structural Determination of CmnG-A, the Adenylation Domain That Activates the Nonproteinogenic Amino Acid Capreomycidine in Capreomycin Biosynthesis.
Chen IH, Cheng T, Wang YL, Huang SJ, Hsiao YH, Lai YT, Toh SI, Chu J, Rudolf JD, Chang CY.
Chen IH, et al. Among authors: toh si.
Chembiochem. 2022 Dec 16;23(24):e202200563. doi: 10.1002/cbic.202200563. Epub 2022 Nov 16.
Chembiochem. 2022.
PMID: 36278314
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Crystal structure of CmnB involved in the biosynthesis of the nonproteinogenic amino acid L-2,3-diaminopropionic acid.
Toh SI, Lo CL, Chang CY.
Toh SI, et al.
Acta Crystallogr F Struct Biol Commun. 2023 Jul 1;79(Pt 7):193-199. doi: 10.1107/S2053230X23005769. Epub 2023 Jul 5.
Acta Crystallogr F Struct Biol Commun. 2023.
PMID: 37405487
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Structural insights into the duplex DNA processing of TREX2.
Cheng HL, Lin CT, Huang KW, Wang S, Lin YT, Toh SI, Hsiao YY.
Cheng HL, et al. Among authors: toh si.
Nucleic Acids Res. 2018 Dec 14;46(22):12166-12176. doi: 10.1093/nar/gky970.
Nucleic Acids Res. 2018.
PMID: 30357414
Free PMC article.
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Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids.
Huang KW, Wu CY, Toh SI, Liu TC, Tu CI, Lin YH, Cheng AJ, Kao YT, Chu JW, Hsiao YY.
Huang KW, et al. Among authors: toh si.
Nucleic Acids Res. 2023 Nov 27;51(21):11927-11940. doi: 10.1093/nar/gkad910.
Nucleic Acids Res. 2023.
PMID: 37870446
Free PMC article.
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Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin.
Toh SI, Elaine Keisha J, Wang YL, Pan YC, Jhu YH, Hsiao PY, Liao WT, Chen PY, Ko TM, Chang CY.
Toh SI, et al.
Commun Biol. 2023 Dec 19;6(1):1282. doi: 10.1038/s42003-023-05681-6.
Commun Biol. 2023.
PMID: 38114770
Free PMC article.
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