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Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets.
Nuytemans K, Lipkin Vasquez M, Wang L, Van Booven D, Griswold AJ, Rajabli F, Celis K, Oron O, Hofmann N, Rolati S, Garcia-Serje C, Zhang S, Jin F, Argenziano M, Grant SFA, Chesi A, Brown CD, Young JI, Dykxhoorn DM, Pericak-Vance MA, Vance JM. Nuytemans K, et al. Among authors: lipkin vasquez m. Alzheimers Dement. 2022 Oct;18(10):1930-1942. doi: 10.1002/alz.12534. Epub 2022 Jan 3. Alzheimers Dement. 2022. PMID: 34978147 Free PMC article.
A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry.
Rajabli F, Beecham GW, Hendrie HC, Baiyewu O, Ogunniyi A, Gao S, Kushch NA, Lipkin-Vasquez M, Hamilton-Nelson KL, Young JI, Dykxhoorn DM, Nuytemans K, Kunkle BW, Wang L, Jin F, Liu X, Feliciano-Astacio BE; Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Genetic Consortium; Schellenberg GD, Dalgard CL, Griswold AJ, Byrd GS, Reitz C, Cuccaro ML, Haines JL, Pericak-Vance MA, Vance JM. Rajabli F, et al. Among authors: lipkin vasquez m. PLoS Genet. 2022 Jul 5;18(7):e1009977. doi: 10.1371/journal.pgen.1009977. eCollection 2022 Jul. PLoS Genet. 2022. PMID: 35788729 Free PMC article.