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A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii.
Jiang X, Patil NA, Azad MAK, Wickremasinghe H, Yu H, Zhao J, Zhang X, Li M, Gong B, Wan L, Ma W, Thompson PE, Yang K, Yuan B, Schreiber F, Wang L, Velkov T, Roberts KD, Li J. Jiang X, et al. Among authors: yu h. Chem Sci. 2021 Aug 19;12(36):12211-12220. doi: 10.1039/d1sc03460j. eCollection 2021 Sep 22. Chem Sci. 2021. PMID: 34667587 Free PMC article.
Polymyxin Triple Combinations against Polymyxin-Resistant, Multidrug-Resistant, KPC-Producing Klebsiella pneumoniae.
Aye SM, Galani I, Yu H, Wang J, Chen K, Wickremasinghe H, Karaiskos I, Bergen PJ, Zhao J, Velkov T, Giamarellou H, Lin YW, Tsuji BT, Li J. Aye SM, et al. Among authors: yu h. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00246-20. doi: 10.1128/AAC.00246-20. Print 2020 Jul 22. Antimicrob Agents Chemother. 2020. PMID: 32393492 Free PMC article.
Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol.
Abdul Rahim N, Cheah SE, Johnson MD, Yu H, Sidjabat HE, Boyce J, Butler MS, Cooper MA, Fu J, Paterson DL, Nation RL, Bergen PJ, Velkov T, Li J. Abdul Rahim N, et al. Among authors: yu h. J Antimicrob Chemother. 2015 Sep;70(9):2589-97. doi: 10.1093/jac/dkv135. Epub 2015 May 28. J Antimicrob Chemother. 2015. PMID: 26023209 Free PMC article.
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