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Imeglimin population pharmacokinetics and dose adjustment predictions for renal impairment in Japanese and Western patients with type 2 diabetes.
Clin Transl Sci. 2022 Apr;15(4):1014-1026. doi: 10.1111/cts.13221. Epub 2022 Jan 17.
Clin Transl Sci. 2022.
PMID: 34962074
Free PMC article.
Target engagement and cellular fate of otelixizumab: a repeat dose escalation study of an anti-CD3ε mAb in new-onset type 1 diabetes mellitus patients.
Vlasakakis G, Napolitano A, Barnard R, Brown K, Bullman J, Inman D, Keymeulen B, Lanham D, Leirens Q, MacDonald A, Mezzalana E, Page K, Patel M, Savage CO, Zamuner S, van Maurik A.
Vlasakakis G, et al. Among authors: mezzalana e.
Br J Clin Pharmacol. 2019 Apr;85(4):704-714. doi: 10.1111/bcp.13842. Epub 2019 Feb 5.
Br J Clin Pharmacol. 2019.
PMID: 30566758
Free PMC article.
Clinical Trial.
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Temporal pharmacokinetic/pharmacodynamic interaction between human CD3ε antigen-targeted monoclonal antibody otelixizumab and CD3ε binding and expression in human peripheral blood mononuclear cell static culture.
Page KR, Mezzalana E, MacDonald AJ, Zamuner S, De Nicolao G, van Maurik A.
Page KR, et al. Among authors: mezzalana e.
J Pharmacol Exp Ther. 2015 Nov;355(2):199-205. doi: 10.1124/jpet.115.224899. Epub 2015 Sep 4.
J Pharmacol Exp Ther. 2015.
PMID: 26341624
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MPBPK-TMDD models for mAbs: alternative models, comparison, and identifiability issues.
Lavezzi SM, Mezzalana E, Zamuner S, De Nicolao G, Ma P, Simeoni M.
Lavezzi SM, et al. Among authors: mezzalana e.
J Pharmacokinet Pharmacodyn. 2018 Dec;45(6):787-802. doi: 10.1007/s10928-018-9608-7. Epub 2018 Nov 10.
J Pharmacokinet Pharmacodyn. 2018.
PMID: 30415351
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Multinomial logistic functions in markov chain models of sleep architecture: internal and external validation and covariate analysis.
Bizzotto R, Zamuner S, Mezzalana E, De Nicolao G, Gomeni R, Hooker AC, Karlsson MO.
Bizzotto R, et al. Among authors: mezzalana e.
AAPS J. 2011 Sep;13(3):445-63. doi: 10.1208/s12248-011-9287-4. Epub 2011 Jun 21.
AAPS J. 2011.
PMID: 21691915
Free PMC article.
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Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development.
Swat MJ, Moodie S, Wimalaratne SM, Kristensen NR, Lavielle M, Mari A, Magni P, Smith MK, Bizzotto R, Pasotti L, Mezzalana E, Comets E, Sarr C, Terranova N, Blaudez E, Chan P, Chard J, Chatel K, Chenel M, Edwards D, Franklin C, Giorgino T, Glont M, Girard P, Grenon P, Harling K, Hooker AC, Kaye R, Keizer R, Kloft C, Kok JN, Kokash N, Laibe C, Laveille C, Lestini G, Mentré F, Munafo A, Nordgren R, Nyberg HB, Parra-Guillen ZP, Plan E, Ribba B, Smith G, Trocóniz IF, Yvon F, Milligan PA, Harnisch L, Karlsson M, Hermjakob H, Le Novère N.
Swat MJ, et al. Among authors: mezzalana e.
CPT Pharmacometrics Syst Pharmacol. 2015 Jun;4(6):316-9. doi: 10.1002/psp4.57. Epub 2015 Jun 15.
CPT Pharmacometrics Syst Pharmacol. 2015.
PMID: 26225259
Free PMC article.
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A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug-Drug-Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine.
Kanacher T, Lindauer A, Mezzalana E, Michon I, Veau C, Mantilla JDG, Nock V, Fleury A.
Kanacher T, et al. Among authors: mezzalana e.
Pharmaceutics. 2020 Dec 8;12(12):1191. doi: 10.3390/pharmaceutics12121191.
Pharmaceutics. 2020.
PMID: 33302490
Free PMC article.
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