Harp JM - Search Results

1

RNAs Containing Carbocyclic Ribonucleotides.

Akabane-Nakata M, Chickering T, Harp JM, Schlegel MK, Matsuda S, Egli M, Manoharan M. Akabane-Nakata M, et al. Among authors: harp jm. Org Lett. 2022 Jan 21;24(2):525-530. doi: 10.1021/acs.orglett.1c03936. Epub 2021 Dec 27. Org Lett. 2022. PMID: 34958225

2

Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.

Kel'in AV, Zlatev I, Harp J, Jayaraman M, Bisbe A, O'Shea J, Taneja N, Manoharan RM, Khan S, Charisse K, Maier MA, Egli M, Rajeev KG, Manoharan M. Kel'in AV, et al. J Org Chem. 2016 Mar 18;81(6):2261-79. doi: 10.1021/acs.joc.5b02375. Epub 2016 Mar 4. J Org Chem. 2016. PMID: 26940174

3

4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.

Malek-Adamian E, Guenther DC, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury J, Perkins L, Moitessier N, Manoharan RM, Taneja N, Bisbe A, Charisse K, Maier M, Rajeev KG, Egli M, Manoharan M, Damha MJ. Malek-Adamian E, et al. J Am Chem Soc. 2017 Oct 18;139(41):14542-14555. doi: 10.1021/jacs.7b07582. Epub 2017 Oct 6. J Am Chem Soc. 2017. PMID: 28937776

4

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.

Kumar P, Degaonkar R, Guenther DC, Abramov M, Schepers G, Capobianco M, Jiang Y, Harp J, Kaittanis C, Janas MM, Castoreno A, Zlatev I, Schlegel MK, Herdewijn P, Egli M, Manoharan M. Kumar P, et al. Nucleic Acids Res. 2020 May 7;48(8):4028-4040. doi: 10.1093/nar/gkaa125. Nucleic Acids Res. 2020. PMID: 32170309 Free PMC article.

5

Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.

Schlegel MK, Foster DJ, Kel'in AV, Zlatev I, Bisbe A, Jayaraman M, Lackey JG, Rajeev KG, Charissé K, Harp J, Pallan PS, Maier MA, Egli M, Manoharan M. Schlegel MK, et al. J Am Chem Soc. 2017 Jun 28;139(25):8537-8546. doi: 10.1021/jacs.7b02694. Epub 2017 Jun 19. J Am Chem Soc. 2017. PMID: 28570818

6

Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.

Schlegel MK, Matsuda S, Brown CR, Harp JM, Barry JD, Berman D, Castoreno A, Schofield S, Szeto J, Manoharan M, Charissé K, Egli M, Maier MA. Schlegel MK, et al. Among authors: harp jm. Nucleic Acids Res. 2021 Nov 8;49(19):10851-10867. doi: 10.1093/nar/gkab916. Nucleic Acids Res. 2021. PMID: 34648028 Free PMC article.

7

Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.

Harp JM, Guenther DC, Bisbe A, Perkins L, Matsuda S, Bommineni GR, Zlatev I, Foster DJ, Taneja N, Charisse K, Maier MA, Rajeev KG, Manoharan M, Egli M. Harp JM, et al. Nucleic Acids Res. 2018 Sep 19;46(16):8090-8104. doi: 10.1093/nar/gky703. Nucleic Acids Res. 2018. PMID: 30107495 Free PMC article.

8

Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.

Pallan PS, Lybrand TP, Schlegel MK, Harp JM, Jahns H, Manoharan M, Egli M. Pallan PS, et al. Among authors: harp jm. Biochemistry. 2020 Dec 15;59(49):4627-4637. doi: 10.1021/acs.biochem.0c00685. Epub 2020 Dec 4. Biochemistry. 2020. PMID: 33275419

9

Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.

Su Y, Patra A, Harp JM, Egli M, Guengerich FP. Su Y, et al. Among authors: harp jm. J Biol Chem. 2015 Jun 26;290(26):15921-33. doi: 10.1074/jbc.M115.653691. Epub 2015 May 6. J Biol Chem. 2015. PMID: 25947374 Free PMC article.

10

Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.

Patra A, Harp J, Pallan PS, Zhao L, Abramov M, Herdewijn P, Egli M. Patra A, et al. Nucleic Acids Res. 2013 Feb 1;41(4):2689-97. doi: 10.1093/nar/gks1316. Epub 2012 Dec 28. Nucleic Acids Res. 2013. PMID: 23275540 Free PMC article.

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