Chang MCY - Search Results

1

Reaction pathway engineering converts a radical hydroxylase into a halogenase.

Neugebauer ME, Kissman EN, Marchand JA, Pelton JG, Sambold NA, Millar DC, Chang MCY. Neugebauer ME, et al. Among authors: chang mcy. Nat Chem Biol. 2022 Feb;18(2):171-179. doi: 10.1038/s41589-021-00944-x. Epub 2021 Dec 22. Nat Chem Biol. 2022. PMID: 34937913

2

Production of isoprenoid pharmaceuticals by engineered microbes.

Chang MC, Keasling JD. Chang MC, et al. Nat Chem Biol. 2006 Dec;2(12):674-81. doi: 10.1038/nchembio836. Nat Chem Biol. 2006. PMID: 17108985

3

Engineering Escherichia coli for production of functionalized terpenoids using plant P450s.

Chang MC, Eachus RA, Trieu W, Ro DK, Keasling JD. Chang MC, et al. Nat Chem Biol. 2007 May;3(5):274-7. doi: 10.1038/nchembio875. Epub 2007 Apr 15. Nat Chem Biol. 2007. PMID: 17438551

4

A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3).

Dietrich JA, Yoshikuni Y, Fisher KJ, Woolard FX, Ockey D, McPhee DJ, Renninger NS, Chang MC, Baker D, Keasling JD. Dietrich JA, et al. ACS Chem Biol. 2009 Apr 17;4(4):261-7. doi: 10.1021/cb900006h. ACS Chem Biol. 2009. PMID: 19271725 Free article.

5

Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways.

Bond-Watts BB, Bellerose RJ, Chang MC. Bond-Watts BB, et al. Nat Chem Biol. 2011 Apr;7(4):222-7. doi: 10.1038/nchembio.537. Epub 2011 Feb 27. Nat Chem Biol. 2011. PMID: 21358636

6

Discovery and Engineering of Pathways for Production of α-Branched Organic Acids.

Blaisse MR, Dong H, Fu B, Chang MCY. Blaisse MR, et al. Among authors: chang mcy. J Am Chem Soc. 2017 Oct 18;139(41):14526-14532. doi: 10.1021/jacs.7b07400. Epub 2017 Oct 9. J Am Chem Soc. 2017. PMID: 28990776

7

Entropy drives selective fluorine recognition in the fluoroacetyl-CoA thioesterase from Streptomyces cattleya.

Weeks AM, Wang N, Pelton JG, Chang MCY. Weeks AM, et al. Among authors: chang mcy. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2193-E2201. doi: 10.1073/pnas.1717077115. Epub 2018 Feb 16. Proc Natl Acad Sci U S A. 2018. PMID: 29453276 Free PMC article.

8

A family of radical halogenases for the engineering of amino-acid-based products.

Neugebauer ME, Sumida KH, Pelton JG, McMurry JL, Marchand JA, Chang MCY. Neugebauer ME, et al. Among authors: chang mcy. Nat Chem Biol. 2019 Oct;15(10):1009-1016. doi: 10.1038/s41589-019-0355-x. Epub 2019 Sep 23. Nat Chem Biol. 2019. PMID: 31548692

9

Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-l-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate.

McBride MJ, Nair MA, Sil D, Slater JW, Neugebauer ME, Chang MCY, Boal AK, Krebs C, Bollinger JM Jr. McBride MJ, et al. Among authors: chang mcy. Biochemistry. 2022 Apr 19;61(8):689-702. doi: 10.1021/acs.biochem.1c00774. Epub 2022 Apr 5. Biochemistry. 2022. PMID: 35380785 Free PMC article.

10

Engineering site-selective incorporation of fluorine into polyketides.

Sirirungruang S, Ad O, Privalsky TM, Ramesh S, Sax JL, Dong H, Baidoo EEK, Amer B, Khosla C, Chang MCY. Sirirungruang S, et al. Among authors: chang mcy. Nat Chem Biol. 2022 Aug;18(8):886-893. doi: 10.1038/s41589-022-01070-y. Epub 2022 Jul 11. Nat Chem Biol. 2022. PMID: 35817967 Free PMC article.

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