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Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2.
Marek M, Ramos-Morales E, Picchi-Constante GFA, Bayer T, Norström C, Herp D, Sales-Junior PA, Guerra-Slompo EP, Hausmann K, Chakrabarti A, Shaik TB, Merz A, Troesch E, Schmidtkunz K, Goldenberg S, Pierce RJ, Mourão MM, Jung M, Schultz J, Sippl W, Zanchin NIT, Romier C. Marek M, et al. Among authors: bayer t. Cell Rep. 2021 Dec 21;37(12):110129. doi: 10.1016/j.celrep.2021.110129. Cell Rep. 2021. PMID: 34936867 Free article.
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.
Herp D, Ridinger J, Robaa D, Shinsky SA, Schmidtkunz K, Yesiloglu TZ, Bayer T, Steimbach RR, Herbst-Gervasoni CJ, Merz A, Romier C, Sehr P, Gunkel N, Miller AK, Christianson DW, Oehme I, Sippl W, Jung M. Herp D, et al. Among authors: bayer t. Chembiochem. 2022 Jul 19;23(14):e202200180. doi: 10.1002/cbic.202200180. Epub 2022 Jun 10. Chembiochem. 2022. PMID: 35608330 Free PMC article.
Histone deacetylases inhibitors as new potential drugs against Leishmania braziliensis, the main causative agent of new world tegumentary leishmaniasis.
Ângelo de Souza L, Silva E Bastos M, de Melo Agripino J, Souza Onofre T, Apaza Calla LF, Heimburg T, Ghazy E, Bayer T, Ferraz da Silva VH, Dutra Ribeiro P, Licursi de Oliveira L, Costa Bressan G, de Almeida Lamêgo MR, Silva-Júnior A, de Souza Vasconcellos R, Suarez-Fontes AM, Almeida-Silva J, Vannier-Santos MA, Pierce R, Sippl W, Lopes Rangel Fietto J. Ângelo de Souza L, et al. Among authors: bayer t. Biochem Pharmacol. 2020 Oct;180:114191. doi: 10.1016/j.bcp.2020.114191. Epub 2020 Aug 7. Biochem Pharmacol. 2020. PMID: 32777278
Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo.
Dorsch W, Wagner H, Bayer T, Fessler B, Hein G, Ring J, Scheftner P, Sieber W, Strasser T, Weiss E. Dorsch W, et al. Among authors: bayer t. Biochem Pharmacol. 1988 Dec 1;37(23):4479-86. doi: 10.1016/0006-2952(88)90663-6. Biochem Pharmacol. 1988. PMID: 2462422
387 results