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Cystic Fibrosis Lung Function Decline after Within-Host Evolution Increases Virulence of Infecting Pseudomonas aeruginosa.
Jorth P, Durfey S, Rezayat A, Garudathri J, Ratjen A, Staudinger BJ, Radey MC, Genatossio A, McNamara S, Cook DA, Aitken ML, Gibson RL, Yahr TL, Singh PK. Jorth P, et al. Among authors: aitken ml. Am J Respir Crit Care Med. 2021 Mar 1;203(5):637-640. doi: 10.1164/rccm.202007-2735LE. Am J Respir Crit Care Med. 2021. PMID: 33137262 Free PMC article. No abstract available.
Regional Isolation Drives Bacterial Diversification within Cystic Fibrosis Lungs.
Jorth P, Staudinger BJ, Wu X, Hisert KB, Hayden H, Garudathri J, Harding CL, Radey MC, Rezayat A, Bautista G, Berrington WR, Goddard AF, Zheng C, Angermeyer A, Brittnacher MJ, Kitzman J, Shendure J, Fligner CL, Mittler J, Aitken ML, Manoil C, Bruce JE, Yahr TL, Singh PK. Jorth P, et al. Among authors: aitken ml. Cell Host Microbe. 2015 Sep 9;18(3):307-19. doi: 10.1016/j.chom.2015.07.006. Epub 2015 Aug 20. Cell Host Microbe. 2015. PMID: 26299432 Free PMC article.
Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.
Goss CH, Kaneko Y, Khuu L, Anderson GD, Ravishankar S, Aitken ML, Lechtzin N, Zhou G, Czyz DM, McLean K, Olakanmi O, Shuman HA, Teresi M, Wilhelm E, Caldwell E, Salipante SJ, Hornick DB, Siehnel RJ, Becker L, Britigan BE, Singh PK. Goss CH, et al. Among authors: aitken ml. Sci Transl Med. 2018 Sep 26;10(460):eaat7520. doi: 10.1126/scitranslmed.aat7520. Sci Transl Med. 2018. PMID: 30257953 Free PMC article. Clinical Trial.
Changes in fecal microbiota with CFTR modulator therapy: A pilot study.
Pope CE, Vo AT, Hayden HS, Weiss EJ, Durfey S, McNamara S, Ratjen A, Grogan B, Carter S, Nay L, Parsek MR, Singh PK, McKone EF, Aitken ML, Rosenfeld MR, Hoffman LR. Pope CE, et al. Among authors: aitken ml. J Cyst Fibros. 2021 Sep;20(5):742-746. doi: 10.1016/j.jcf.2020.12.002. Epub 2020 Dec 31. J Cyst Fibros. 2021. PMID: 33390317 Free PMC article.
189 results