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High-Throughput Screening Reveals New Glutaminase Inhibitor Molecules.
E Costa RK, Rodrigues CT, H Campos JC, Paradela LS, Dias MM, Novaes da Silva B, de Valega Negrao CVZ, Gonçalves KA, Ascenção CFR, Adamoski D, Mercaldi GF, Bastos ACS, Batista FAH, Figueira AC, Cordeiro AT, Ambrosio ALB, Guido RVC, Dias SMG. E Costa RK, et al. Among authors: goncalves ka. ACS Pharmacol Transl Sci. 2021 Dec 1;4(6):1849-1866. doi: 10.1021/acsptsci.1c00226. eCollection 2021 Dec 10. ACS Pharmacol Transl Sci. 2021. PMID: 34927015 Free PMC article.
Active glutaminase C self-assembles into a supratetrameric oligomer that can be disrupted by an allosteric inhibitor.
Ferreira AP, Cassago A, Gonçalves Kde A, Dias MM, Adamoski D, Ascenção CF, Honorato RV, de Oliveira JF, Ferreira IM, Fornezari C, Bettini J, Oliveira PS, Paes Leme AF, Portugal RV, Ambrosio AL, Dias SM. Ferreira AP, et al. J Biol Chem. 2013 Sep 27;288(39):28009-20. doi: 10.1074/jbc.M113.501346. Epub 2013 Aug 8. J Biol Chem. 2013. PMID: 23935106 Free PMC article.
Insights into the full-length SRPK2 structure and its hydrodynamic behavior.
Barbosa ÉAA, Seraphim TV, Gandin CA, Teixeira LF, da Silva RAG, Righetto GL, Goncalves KA, Vasconcellos RS, Almeida MR, Silva Júnior A, Fietto JLR, Kobarg J, Gileadi C, Massirer KB, Borges JC, de Oliveira Neto M, Bressan GC. Barbosa ÉAA, et al. Among authors: goncalves ka. Int J Biol Macromol. 2019 Sep 15;137:205-214. doi: 10.1016/j.ijbiomac.2019.06.135. Epub 2019 Jun 20. Int J Biol Macromol. 2019. PMID: 31229549
28 results