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Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
J Exp Med. 2022 Jan 3;219(1):e20201039. doi: 10.1084/jem.20201039. Epub 2021 Dec 17.
J Exp Med. 2022.
PMID: 34919140
Free PMC article.
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S.
Schmidt S, et al. Among authors: bolik j.
J Exp Med. 2018 Apr 2;215(4):1205-1225. doi: 10.1084/jem.20171696. Epub 2018 Feb 22.
J Exp Med. 2018.
PMID: 29472497
Free PMC article.
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Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17.
Müller M, Saunders C, Senftleben A, Heidbuechel JPW, Halwachs B, Bolik J, Hedemann N, Röder C, Bauerschlag D, Rose-John S, Schmidt-Arras D.
Müller M, et al. Among authors: bolik j.
Cells. 2022 Aug 29;11(17):2683. doi: 10.3390/cells11172683.
Cells. 2022.
PMID: 36078095
Free PMC article.
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IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.
Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mittrücker HW, Rose-John S, Schmidt-Arras D.
Bergmann J, et al. Among authors: bolik j.
Hepatology. 2017 Jan;65(1):89-103. doi: 10.1002/hep.28874. Epub 2016 Nov 22.
Hepatology. 2017.
PMID: 27770462
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The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis.
Fuchslocher Chico J, Falk-Paulsen M, Luzius A, Saggau C, Ruder B, Bolik J, Schmidt-Arras D, Linkermann A, Becker C, Rosenstiel P, Rose-John S, Adam D.
Fuchslocher Chico J, et al. Among authors: bolik j.
Oncotarget. 2018 Feb 5;9(16):12941-12958. doi: 10.18632/oncotarget.24410. eCollection 2018 Feb 27.
Oncotarget. 2018.
PMID: 29560122
Free PMC article.
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Gut microbiota shape 'inflamm-ageing' cytokines and account for age-dependent decline in DNA damage repair.
Guedj A, Volman Y, Geiger-Maor A, Bolik J, Schumacher N, Künzel S, Baines JF, Nevo Y, Elgavish S, Galun E, Amsalem H, Schmidt-Arras D, Rachmilewitz J.
Guedj A, et al. Among authors: bolik j.
Gut. 2020 Jun;69(6):1064-1075. doi: 10.1136/gutjnl-2019-318491. Epub 2019 Oct 5.
Gut. 2020.
PMID: 31586932
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Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice.
Schumacher N, Yan K, Gandraß M, Müller M, Krisp C, Häsler R, Carambia A, Nofer JR, Bernardes JP, Khouja M, Thomsen I, Chalupsky K, Bolik J, Hölscher C, Wunderlich T, Herkel J, Rosenstiel P, Schramm C, Schlüter H, Renné T, Mittrücker HW, Rose-John S, Schmidt-Arras D.
Schumacher N, et al. Among authors: bolik j.
J Hepatol. 2021 Feb;74(2):407-418. doi: 10.1016/j.jhep.2020.09.021. Epub 2020 Sep 25.
J Hepatol. 2021.
PMID: 32987028
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Early heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2-/- mice.
Barikbin R, Berkhout L, Bolik J, Schmidt-Arras D, Ernst T, Ittrich H, Adam G, Parplys A, Casar C, Krech T, Karimi K, Sass G, Tiegs G.
Barikbin R, et al. Among authors: bolik j.
Sci Rep. 2018 Nov 2;8(1):16238. doi: 10.1038/s41598-018-33233-0.
Sci Rep. 2018.
PMID: 30389969
Free PMC article.
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