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CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation.
Otano I, Azpilikueta A, Glez-Vaz J, Alvarez M, Medina-Echeverz J, Cortés-Domínguez I, Ortiz-de-Solorzano C, Ellmark P, Fritzell S, Hernandez-Hoyos G, Nelson MH, Ochoa MC, Bolaños E, Cuculescu D, Jaúregui P, Sanchez-Gregorio S, Etxeberria I, Rodriguez-Ruiz ME, Sanmamed MF, Teijeira Á, Berraondo P, Melero I. Otano I, et al. Among authors: berraondo p. Nat Commun. 2021 Dec 15;12(1):7296. doi: 10.1038/s41467-021-27613-w. Nat Commun. 2021. PMID: 34911975 Free PMC article.
Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma.
Tirapu I, Huarte E, Guiducci C, Arina A, Zaratiegui M, Murillo O, Gonzalez A, Berasain C, Berraondo P, Fortes P, Prieto J, Colombo MP, Chen L, Melero I. Tirapu I, et al. Among authors: berraondo p. Cancer Res. 2006 Feb 15;66(4):2442-50. doi: 10.1158/0008-5472.CAN-05-1681. Cancer Res. 2006. PMID: 16489051 Free article.
In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb.
Murillo O, Dubrot J, Palazón A, Arina A, Azpilikueta A, Alfaro C, Solano S, Ochoa MC, Berasain C, Gabari I, Pérez-Gracia JL, Berraondo P, Hervás-Stubbs S, Melero I. Murillo O, et al. Among authors: berraondo p. Eur J Immunol. 2009 Sep;39(9):2424-36. doi: 10.1002/eji.200838958. Eur J Immunol. 2009. PMID: 19662633 Free article.
Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice.
Gonzalez-Aparicio M, Alzuguren P, Mauleon I, Medina-Echeverz J, Hervas-Stubbs S, Mancheno U, Berraondo P, Crettaz J, Gonzalez-Aseguinolaza G, Prieto J, Hernandez-Alcoceba R. Gonzalez-Aparicio M, et al. Among authors: berraondo p. Gut. 2011 Mar;60(3):341-9. doi: 10.1136/gut.2010.211722. Epub 2010 Sep 20. Gut. 2011. PMID: 20855451 Free article.
Development of a liver-specific Tet-on inducible system for AAV vectors and its application in the treatment of liver cancer.
Vanrell L, Di Scala M, Blanco L, Otano I, Gil-Farina I, Baldim V, Paneda A, Berraondo P, Beattie SG, Chtarto A, Tenenbaum L, Prieto J, Gonzalez-Aseguinolaza G. Vanrell L, et al. Among authors: berraondo p. Mol Ther. 2011 Jul;19(7):1245-53. doi: 10.1038/mt.2011.37. Epub 2011 Mar 1. Mol Ther. 2011. PMID: 21364542 Free PMC article.
166 results