Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

16 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.
Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, Walter P, Ashkenazi A. Le Thomas A, et al. Nat Commun. 2021 Dec 15;12(1):7310. doi: 10.1038/s41467-021-27597-7. Nat Commun. 2021. PMID: 34911951 Free PMC article.
Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A. Harnoss JM, et al. Among authors: le thomas a. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16420-16429. doi: 10.1073/pnas.1906999116. Epub 2019 Aug 1. Proc Natl Acad Sci U S A. 2019. PMID: 31371506 Free PMC article.
IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment.
Harnoss JM, Le Thomas A, Reichelt M, Guttman O, Wu TD, Marsters SA, Shemorry A, Lawrence DA, Kan D, Segal E, Merchant M, Totpal K, Crocker LM, Mesh K, Dohse M, Solon M, Modrusan Z, Rudolph J, Koeppen H, Walter P, Ashkenazi A. Harnoss JM, et al. Among authors: le thomas a. Cancer Res. 2020 Jun 1;80(11):2368-2379. doi: 10.1158/0008-5472.CAN-19-3108. Epub 2020 Apr 7. Cancer Res. 2020. PMID: 32265225 Free PMC article.
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands.
Ferri E, Le Thomas A, Wallweber HA, Day ES, Walters BT, Kaufman SE, Braun MG, Clark KR, Beresini MH, Mortara K, Chen YA, Canter B, Phung W, Liu PS, Lammens A, Ashkenazi A, Rudolph J, Wang W. Ferri E, et al. Among authors: le thomas a. Nat Commun. 2020 Dec 14;11(1):6387. doi: 10.1038/s41467-020-19974-5. Nat Commun. 2020. PMID: 33318494 Free PMC article.
Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay.
Cairrão F, Santos CC, Le Thomas A, Marsters S, Ashkenazi A, Domingos PM. Cairrão F, et al. Among authors: le thomas a. Nat Commun. 2022 Mar 24;13(1):1587. doi: 10.1038/s41467-022-29105-x. Nat Commun. 2022. PMID: 35332141 Free PMC article.
Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors.
Chen YA, Stuwe E, Luo Y, Ninova M, Le Thomas A, Rozhavskaya E, Li S, Vempati S, Laver JD, Patel DJ, Smibert CA, Lipshitz HD, Toth KF, Aravin AA. Chen YA, et al. Among authors: le thomas a. Mol Cell. 2016 Jul 7;63(1):97-109. doi: 10.1016/j.molcel.2016.05.010. Epub 2016 Jun 9. Mol Cell. 2016. PMID: 27292797 Free PMC article.
A framework for piRNA cluster manipulation.
Olovnikov I, Le Thomas A, Aravin AA. Olovnikov I, et al. Among authors: le thomas a. Methods Mol Biol. 2014;1093:47-58. doi: 10.1007/978-1-62703-694-8_5. Methods Mol Biol. 2014. PMID: 24178556
16 results