Souers AJ - Search Results

1

Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin.

Ahmadinejad F, Bos T, Hu B, Britt E, Koblinski J, Souers AJ, Leverson JD, Faber AC, Gewirtz DA, Harada H. Ahmadinejad F, et al. Among authors: souers aj. Mol Pharmacol. 2022 Mar;101(3):168-180. doi: 10.1124/molpharm.121.000354. Epub 2021 Dec 14. Mol Pharmacol. 2022. PMID: 34907000 Free PMC article.

2

Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy.

Carpenter V, Saleh T, Min Lee S, Murray G, Reed J, Souers A, Faber AC, Harada H, Gewirtz DA. Carpenter V, et al. Biochem Pharmacol. 2021 Nov;193:114765. doi: 10.1016/j.bcp.2021.114765. Epub 2021 Sep 15. Biochem Pharmacol. 2021. PMID: 34536356

3

Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X_L -BAX interaction.

Saleh T, Carpenter VJ, Tyutyunyk-Massey L, Murray G, Leverson JD, Souers AJ, Alotaibi MR, Faber AC, Reed J, Harada H, Gewirtz DA. Saleh T, et al. Among authors: souers aj. Mol Oncol. 2020 Oct;14(10):2504-2519. doi: 10.1002/1878-0261.12761. Epub 2020 Aug 5. Mol Oncol. 2020. PMID: 32652830 Free PMC article.

4

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor.

Xiao Y, Nimmer P, Sheppard GS, Bruncko M, Hessler P, Lu X, Roberts-Rapp L, Pappano WN, Elmore SW, Souers AJ, Leverson JD, Phillips DC. Xiao Y, et al. Among authors: souers aj. Mol Cancer Ther. 2015 Aug;14(8):1837-47. doi: 10.1158/1535-7163.MCT-14-0928. Epub 2015 May 26. Mol Cancer Ther. 2015. PMID: 26013319

5

Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer.

Zhang H, Xue J, Hessler P, Tahir SK, Chen J, Jin S, Souers AJ, Leverson JD, Lam LT. Zhang H, et al. Among authors: souers aj. Mol Cancer. 2015 Jul 2;14:126. doi: 10.1186/s12943-015-0397-y. Mol Cancer. 2015. PMID: 26134786 Free PMC article.

6

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.

Ashkenazi A, Fairbrother WJ, Leverson JD, Souers AJ. Ashkenazi A, et al. Among authors: souers aj. Nat Rev Drug Discov. 2017 Apr;16(4):273-284. doi: 10.1038/nrd.2016.253. Epub 2017 Feb 17. Nat Rev Drug Discov. 2017. PMID: 28209992 Review.

7

Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression.

Lochmann TL, Floros KV, Naseri M, Powell KM, Cook W, March RJ, Stein GT, Greninger P, Maves YK, Saunders LR, Dylla SJ, Costa C, Boikos SA, Leverson JD, Souers AJ, Krystal GW, Harada H, Benes CH, Faber AC. Lochmann TL, et al. Among authors: souers aj. Clin Cancer Res. 2018 Jan 15;24(2):360-369. doi: 10.1158/1078-0432.CCR-17-1606. Epub 2017 Nov 8. Clin Cancer Res. 2018. PMID: 29118061 Free PMC article.

8

Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy.

Floros KV, Lochmann TL, Hu B, Monterrubio C, Hughes MT, Wells JD, Morales CB, Ghotra MS, Costa C, Souers AJ, Boikos SA, Leverson JD, Tan M, Serra V, Koblinski JE, Arribas J, Prat A, Paré L, Miller TW, Dozmorov MG, Harada H, Windle BE, Scaltriti M, Faber AC. Floros KV, et al. Among authors: souers aj. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2594-E2603. doi: 10.1073/pnas.1717820115. Epub 2018 Feb 23. Proc Natl Acad Sci U S A. 2018. PMID: 29476008 Free PMC article.

9

Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR-Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target.

Song KA, Hosono Y, Turner C, Jacob S, Lochmann TL, Murakami Y, Patel NU, Ham J, Hu B, Powell KM, Coon CM, Windle BE, Oya Y, Koblinski JE, Harada H, Leverson JD, Souers AJ, Hata AN, Boikos S, Yatabe Y, Ebi H, Faber AC. Song KA, et al. Among authors: souers aj. Clin Cancer Res. 2018 Nov 15;24(22):5658-5672. doi: 10.1158/1078-0432.CCR-18-0304. Epub 2018 Aug 7. Clin Cancer Res. 2018. PMID: 30087143

10

The Ewing Family of Tumors Relies on BCL-2 and BCL-X_L to Escape PARP Inhibitor Toxicity.

Heisey DAR, Lochmann TL, Floros KV, Coon CM, Powell KM, Jacob S, Calbert ML, Ghotra MS, Stein GT, Maves YK, Smith SC, Benes CH, Leverson JD, Souers AJ, Boikos SA, Faber AC. Heisey DAR, et al. Among authors: souers aj. Clin Cancer Res. 2019 Mar 1;25(5):1664-1675. doi: 10.1158/1078-0432.CCR-18-0277. Epub 2018 Oct 22. Clin Cancer Res. 2019. PMID: 30348635

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