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A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer.
Liu S, Li D, Liu J, Wang H, Horecny I, Shen R, Zhang R, Wu H, Hu Q, Zhao P, Zhang F, Yan Y, Feng J, Zhuang L, Li J, Zhang L, Tao W. Liu S, et al. Among authors: zhao p. Onco Targets Ther. 2021 Aug 24;14:4561-4574. doi: 10.2147/OTT.S326178. eCollection 2021. Onco Targets Ther. 2021. PMID: 34466002 Free PMC article.
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
Wang A, Li X, Wu H, Zou F, Yan XE, Chen C, Hu C, Yu K, Wang W, Zhao P, Wu J, Qi Z, Wang W, Wang B, Wang L, Ren T, Zhang S, Yun CH, Liu J, Liu Q. Wang A, et al. Among authors: zhao p. J Med Chem. 2017 Apr 13;60(7):2944-2962. doi: 10.1021/acs.jmedchem.6b01907. Epub 2017 Mar 22. J Med Chem. 2017. PMID: 28282122
Structural Basis of AZD9291 Selectivity for EGFR T790M.
Yan XE, Ayaz P, Zhu SJ, Zhao P, Liang L, Zhang CH, Wu YC, Li JL, Choi HG, Huang X, Shan Y, Shaw DE, Yun CH. Yan XE, et al. Among authors: zhao p. J Med Chem. 2020 Aug 13;63(15):8502-8511. doi: 10.1021/acs.jmedchem.0c00891. Epub 2020 Aug 3. J Med Chem. 2020. PMID: 32672461
Structural pharmacological studies on EGFR T790M/C797S.
Kong LL, Ma R, Yao MY, Yan XE, Zhu SJ, Zhao P, Yun CH. Kong LL, et al. Among authors: zhao p. Biochem Biophys Res Commun. 2017 Jun 24;488(2):266-272. doi: 10.1016/j.bbrc.2017.04.138. Epub 2017 Apr 26. Biochem Biophys Res Commun. 2017. PMID: 28456628
Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells.
Wu H, Wang A, Zhang W, Wang B, Chen C, Wang W, Hu C, Ye Z, Zhao Z, Wang L, Li X, Yu K, Liu J, Wu J, Yan XE, Zhao P, Wang J, Wang C, Weisberg EL, Gray NS, Yun CH, Liu J, Chen L, Liu Q. Wu H, et al. Among authors: zhao z, zhao p. Oncotarget. 2015 Oct 13;6(31):31313-22. doi: 10.18632/oncotarget.5182. Oncotarget. 2015. PMID: 26375053 Free PMC article.
9,001 results