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Toward Individualized Prediction of Response to Methotrexate in Early Rheumatoid Arthritis: A Pharmacogenomics-Driven Machine Learning Approach.
Myasoedova E, Athreya AP, Crowson CS, Davis JM 3rd, Warrington KJ, Walchak RC, Carlson E, Kalari KR, Bongartz T, Tak PP, van Vollenhoven RF, Padyukov L, Emery P, Morgan A, Wang L, Weinshilboum RM, Matteson EL; Pharmacogenetics of Methotrexate in Rheumatoid Arthritis Consortium. Myasoedova E, et al. Among authors: morgan a. Arthritis Care Res (Hoboken). 2022 Jun;74(6):879-888. doi: 10.1002/acr.24834. Epub 2022 Apr 6. Arthritis Care Res (Hoboken). 2022. PMID: 34902228 Free article.
Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia.
Ponchel F, Verburg RJ, Bingham SJ, Brown AK, Moore J, Protheroe A, Short K, Lawson CA, Morgan AW, Quinn M, Buch M, Field SL, Maltby SL, Masurel A, Douglas SH, Straszynski L, Fearon U, Veale DJ, Patel P, McGonagle D, Snowden J, Markham AF, Ma D, van Laar JM, Papadaki HA, Emery P, Isaacs JD. Ponchel F, et al. Among authors: morgan aw. Arthritis Res Ther. 2005;7(1):R80-92. doi: 10.1186/ar1452. Epub 2004 Nov 16. Arthritis Res Ther. 2005. PMID: 15642146 Free PMC article.
Analysis of Fcgamma receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B.
Morgan AW, Barrett JH, Griffiths B, Subramanian D, Robinson JI, Keyte VH, Ali M, Jones EA, Old RW, Ponchel F, Boylston AW, Situnayake RD, Markham AF, Emery P, Isaacs JD. Morgan AW, et al. Arthritis Res Ther. 2006;8(1):R5. doi: 10.1186/ar1847. Arthritis Res Ther. 2006. PMID: 16356189 Free PMC article.
Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population.
Morgan AW, Thomson W, Martin SG; Yorkshire Early Arthritis Register Consortium; Carter AM; UK Rheumatoid Arthritis Genetics Consortium; Erlich HA, Barton A, Hocking L, Reid DM, Harrison P, Wordsworth P, Steer S, Worthington J, Emery P, Wilson AG, Barrett JH. Morgan AW, et al. Arthritis Rheum. 2009 Sep;60(9):2565-76. doi: 10.1002/art.24752. Arthritis Rheum. 2009. PMID: 19714585 Free article.
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG; BIRAC Consortium; Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P; YEAR Consortium; Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM. Raychaudhuri S, et al. Among authors: morgan aw. Nat Genet. 2009 Dec;41(12):1313-8. doi: 10.1038/ng.479. Epub 2009 Nov 8. Nat Genet. 2009. PMID: 19898481 Free PMC article.
Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis.
Hassan B, Maxwell JR, Hyrich KL; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate; Barton A, Worthington J, Isaacs JD, Morgan AW, Wilson AG. Hassan B, et al. Among authors: morgan aw. Rheumatology (Oxford). 2010 Jan;49(1):43-7. doi: 10.1093/rheumatology/kep372. Epub 2009 Nov 19. Rheumatology (Oxford). 2010. PMID: 19926672
Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.
Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedrén S, Ding B, Guiducci C, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TW, Tak PP, Bridges SL Jr, Toes RE, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge RM. Cui J, et al. Among authors: morgan aw. Arthritis Rheum. 2010 Jul;62(7):1849-61. doi: 10.1002/art.27457. Arthritis Rheum. 2010. PMID: 20309874 Free PMC article.
Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.
Morgan AW, Robinson JI, Conaghan PG, Martin SG, Hensor EM, Morgan MD, Steiner L, Erlich HA, Gooi HC, Barton A, Worthington J, Emery P; UKRAG Consortium; YEAR Consortium. Morgan AW, et al. Among authors: morgan md. Arthritis Res Ther. 2010;12(2):R57. doi: 10.1186/ar2969. Epub 2010 Mar 30. Arthritis Res Ther. 2010. PMID: 20353580 Free PMC article.
3,338 results