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IKKβ is an IRF5 kinase that instigates inflammation.
Ren J, Chen X, Chen ZJ. Ren J, et al. Among authors: chen zj, chen x. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17438-43. doi: 10.1073/pnas.1418516111. Epub 2014 Oct 17. Proc Natl Acad Sci U S A. 2014. PMID: 25326420 Free PMC article.
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Gao D, Li T, Li XD, Chen X, Li QZ, Wight-Carter M, Chen ZJ. Gao D, et al. Among authors: chen zj, chen x. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5699-705. doi: 10.1073/pnas.1516465112. Epub 2015 Sep 14. Proc Natl Acad Sci U S A. 2015. PMID: 26371324 Free PMC article.
cGAS restricts colon cancer development by protecting intestinal barrier integrity.
Hu S, Fang Y, Chen X, Cheng T, Zhao M, Du M, Li T, Li M, Zeng Z, Wei Y, Gu Z, Zhang C, Sun L, Chen ZJ. Hu S, et al. Among authors: chen zj, chen x. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2105747118. doi: 10.1073/pnas.2105747118. Proc Natl Acad Sci U S A. 2021. PMID: 34074794 Free PMC article.
cGAS is essential for the antitumor effect of immune checkpoint blockade.
Wang H, Hu S, Chen X, Shi H, Chen C, Sun L, Chen ZJ. Wang H, et al. Among authors: chen zj, chen c, chen x. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1637-1642. doi: 10.1073/pnas.1621363114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137885 Free PMC article.
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