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Single center, open label dose escalating trial evaluating once weekly oral ixazomib in ART-suppressed, HIV positive adults and effects on HIV reservoir size in vivo.
Cummins NW, Baker J, Chakraborty R, Dean PG, Garcia-Rivera E, Krogman A, Kumar S, Kuzmichev YV, Laird GM, Landay A, Lichterfeld M, Mahmood M, Martinson J, Maynes M, Natesampillai S, Rajkumar V, Rassadkina Y, Ritter KD, Rivera CG, Rizza SA, Subramanian K, Tande AJ, Wonderlich ER, Whitaker JA, Zeuli J, Badley AD. Cummins NW, et al. Among authors: ritter kd. EClinicalMedicine. 2021 Nov 29;42:101225. doi: 10.1016/j.eclinm.2021.101225. eCollection 2021 Dec. EClinicalMedicine. 2021. PMID: 34901797 Free PMC article.
Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA.
Simonetti FR, White JA, Tumiotto C, Ritter KD, Cai M, Gandhi RT, Deeks SG, Howell BJ, Montaner LJ, Blankson JN, Martin A, Laird GM, Siliciano RF, Mellors JW, Siliciano JD. Simonetti FR, et al. Among authors: ritter kd. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18692-18700. doi: 10.1073/pnas.2006816117. Epub 2020 Jul 20. Proc Natl Acad Sci U S A. 2020. PMID: 32690683 Free PMC article.
Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.
Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S. Yukl SA, et al. Among authors: ritter kd. J Virol. 2020 Dec 22;95(2):e01331-20. doi: 10.1128/JVI.01331-20. Print 2020 Dec 22. J Virol. 2020. PMID: 33115867 Free PMC article.
Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV Disease.
Barbehenn A, Shi L, Shao J, Hoh R, Hartig HM, Pae V, Sarvadhavabhatla S, Donaire S, Sheikhzadeh C, Milush J, Laird GM, Mathias M, Ritter K, Peluso M, Martin J, Hecht F, Pilcher C, Cohen SE, Buchbinder S, Havlir D, Gandhi M, Henrich TJ, Hatano H, Wang J, Deeks SG, Lee SA. Barbehenn A, et al. medRxiv [Preprint]. 2024 Mar 28:2024.03.27.24304867. doi: 10.1101/2024.03.27.24304867. medRxiv. 2024. PMID: 38585951 Free PMC article. Preprint.