Pu J - Search Results

1

Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators.

Qiu Y, Wang Y, Chai Z, Ni D, Li X, Pu J, Chen J, Zhang J, Lu S, Lv C, Ji M. Qiu Y, et al. Among authors: pu j. Acta Pharm Sin B. 2021 Nov;11(11):3433-3446. doi: 10.1016/j.apsb.2021.02.014. Epub 2021 Feb 25. Acta Pharm Sin B. 2021. PMID: 34900528 Free PMC article. Review.

2

Emergence of allosteric drug-resistance mutations: new challenges for allosteric drug discovery.

Lu S, Qiu Y, Ni D, He X, Pu J, Zhang J. Lu S, et al. Among authors: pu j. Drug Discov Today. 2020 Jan;25(1):177-184. doi: 10.1016/j.drudis.2019.10.006. Epub 2019 Oct 18. Drug Discov Today. 2020. PMID: 31634592 Review.

3

Combining Allosteric and Orthosteric Drugs to Overcome Drug Resistance.

Ni D, Li Y, Qiu Y, Pu J, Lu S, Zhang J. Ni D, et al. Among authors: pu j. Trends Pharmacol Sci. 2020 May;41(5):336-348. doi: 10.1016/j.tips.2020.02.001. Epub 2020 Mar 12. Trends Pharmacol Sci. 2020. PMID: 32171554 Review.

4

Computational methods-guided design of modulators targeting protein-protein interactions (PPIs).

Qiu Y, Li X, He X, Pu J, Zhang J, Lu S. Qiu Y, et al. Among authors: pu j. Eur J Med Chem. 2020 Dec 1;207:112764. doi: 10.1016/j.ejmech.2020.112764. Epub 2020 Aug 23. Eur J Med Chem. 2020. PMID: 32871340 Review.

5

Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins.

Wang Y, Ji D, Lei C, Chen Y, Qiu Y, Li X, Li M, Ni D, Pu J, Zhang J, Fu Q, Liu Y, Lu S. Wang Y, et al. Among authors: pu j. Comput Struct Biotechnol J. 2021 Feb 9;19:1184-1199. doi: 10.1016/j.csbj.2021.01.044. eCollection 2021. Comput Struct Biotechnol J. 2021. PMID: 33680360 Free PMC article.

6

Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy.

Ni D, Wei J, He X, Rehman AU, Li X, Qiu Y, Pu J, Lu S, Zhang J. Ni D, et al. Among authors: pu j. Chem Sci. 2020 Nov 2;12(1):464-476. doi: 10.1039/d0sc05131d. Chem Sci. 2020. PMID: 34163609 Free PMC article.

7

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design.

Lu S, He X, Yang Z, Chai Z, Zhou S, Wang J, Rehman AU, Ni D, Pu J, Sun J, Zhang J. Lu S, et al. Among authors: pu j. Nat Commun. 2021 Aug 5;12(1):4721. doi: 10.1038/s41467-021-25020-9. Nat Commun. 2021. PMID: 34354057 Free PMC article.

8

Single Bolus r-SAK Before Primary PCI for ST-Segment-Elevation Myocardial Infarction.

Chen P, Eikelboom JW, Tan C, Zhang W, Xu Y, Bai J, Wang J, Wang T, Gong X, Liu K, Chen X, Wang X, Zhu L, Zhao X, Yang N, Jiang J, Pu J, Zhao B, Chen Z, Li B, Wang G, Lu C, Ying L, Jiang M, Zhu X, Ma J, Dong Z, Li C, Zong J, Zhang F, Zhu J, Huang J, Kong X, Yu H, Li C; OPTIMA-5 Investigators. Chen P, et al. Among authors: pu j. Circ Cardiovasc Interv. 2024 Feb;17(2):e013455. doi: 10.1161/CIRCINTERVENTIONS.123.013455. Epub 2024 Jan 23. Circ Cardiovasc Interv. 2024. PMID: 38258563 Clinical Trial.

9

Differentiation and Application of Human Pluripotent Stem Cells Derived Cardiovascular Cells for Treatment of Heart Diseases: Promises and Challenges.

Gao Y, Pu J. Gao Y, et al. Among authors: pu j. Front Cell Dev Biol. 2021 May 12;9:658088. doi: 10.3389/fcell.2021.658088. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34055788 Free PMC article. Review.

10

Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.

Sun LY, Lyu YY, Zhang HY, Shen Z, Lin GQ, Geng N, Wang YL, Huang L, Feng ZH, Guo X, Lin N, Ding S, Yuan AC, Zhang L, Qian K, Pu J. Sun LY, et al. Among authors: pu j. Circulation. 2022 Nov 22;146(21):1591-1609. doi: 10.1161/CIRCULATIONAHA.121.057623. Epub 2022 Jul 26. Circulation. 2022. PMID: 35880522 Free PMC article.

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