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Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells.
J Biol Chem. 2022 Jan;298(1):101477. doi: 10.1016/j.jbc.2021.101477. Epub 2021 Dec 10.
J Biol Chem. 2022.
PMID: 34896393
Free PMC article.
Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.
Bata N, Chaikuad A, Bakas NA, Limpert AS, Lambert LJ, Sheffler DJ, Berger LM, Liu G, Yuan C, Wang L, Peng Y, Dong J, Celeridad M, Layng F, Knapp S, Cosford NDP.
Bata N, et al.
J Med Chem. 2022 Jan 27;65(2):1352-1369. doi: 10.1021/acs.jmedchem.1c00804. Epub 2021 Nov 22.
J Med Chem. 2022.
PMID: 34807584
Free PMC article.
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Absence of HIF1A Leads to Glycogen Accumulation and an Inflammatory Response That Enables Pancreatic Tumor Growth.
Maruggi M, Layng FI, Lemos R Jr, Garcia G, James BP, Sevilla M, Soldevilla F, Baaten BJ, de Jong PR, Koh MY, Powis G.
Maruggi M, et al. Among authors: layng fi.
Cancer Res. 2019 Nov 15;79(22):5839-5848. doi: 10.1158/0008-5472.CAN-18-2994. Epub 2019 Oct 4.
Cancer Res. 2019.
PMID: 31585939
Free PMC article.
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PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.
Jeung HC, Puentes R, Aleshin A, Indarte M, Correa RG, Bankston LA, Layng FIAL, Ahmed Z, Wistuba I, Yao Y, Duenas DG, Zhang S, Meuillet EJ, Marassi F, Liddington RC, Kirkpatrick L, Powis G.
Jeung HC, et al. Among authors: layng fial.
Exp Cell Res. 2021 Dec 15;409(2):112930. doi: 10.1016/j.yexcr.2021.112930. Epub 2021 Nov 17.
Exp Cell Res. 2021.
PMID: 34800542
Free PMC article.
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MicroRNA-211 Modulates the DUSP6-ERK5 Signaling Axis to Promote BRAFV600E-Driven Melanoma Growth In Vivo and BRAF/MEK Inhibitor Resistance.
Lee B, Sahoo A, Sawada J, Marchica J, Sahoo S, Layng FIAL, Finlay D, Mazar J, Joshi P, Komatsu M, Vuori K, de Jong PR, Ray A, Perera RJ.
Lee B, et al. Among authors: layng fial.
J Invest Dermatol. 2021 Feb;141(2):385-394. doi: 10.1016/j.jid.2020.06.038. Epub 2020 Sep 2.
J Invest Dermatol. 2021.
PMID: 32888955
Free PMC article.
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Correction: An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.
Indarte M, Puentes R, Maruggi M, Ihle NT, Grandjean G, Scott M, Ahmed Z, Meuillet EJ, Zhang S, Lemos R Jr, Du-Cuny L, Layng FIAL, Correa RG, Bankston LA, Liddington RC, Kirkpatrick L, Powis G.
Indarte M, et al. Among authors: layng fial.
Cancer Res. 2019 Oct 15;79(20):5457. doi: 10.1158/0008-5472.CAN-19-2586.
Cancer Res. 2019.
PMID: 31615811
No abstract available.
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An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.
Indarte M, Puentes R, Maruggi M, Ihle NT, Grandjean G, Scott M, Ahmed Z, Meuillet EJ, Zang S, Lemos R Jr, Du-Cuny L, Layng FIAL, Correa RG, Bankston LA, Liddington RC, Kirkpatrick L, Powis G.
Indarte M, et al. Among authors: layng fial.
Cancer Res. 2019 Jun 15;79(12):3100-3111. doi: 10.1158/0008-5472.CAN-18-2372. Epub 2019 Apr 30.
Cancer Res. 2019.
PMID: 31040156
Free PMC article.
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