Gee CT - Search Results

1

Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket.

Fernando DM, Gee CT, Griffith EC, Meyer CJ, Wilt LA, Tangallapally R, Wallace MJ, Miller DJ, Lee RE. Fernando DM, et al. Among authors: gee ct. Tuberculosis (Edinb). 2022 Jan;132:102157. doi: 10.1016/j.tube.2021.102157. Epub 2021 Nov 29. Tuberculosis (Edinb). 2022. PMID: 34894561 Free PMC article.

2

Mechanisms of Resistance Associated with the Inhibition of the Dehydration Step of Type II Fatty Acid Synthase in Mycobacterium tuberculosis.

Grzegorzewicz AE, Gee C, Das S, Liu J, Belardinelli JM, Jones V, McNeil MR, Lee RE, Jackson M. Grzegorzewicz AE, et al. ACS Infect Dis. 2020 Feb 14;6(2):195-204. doi: 10.1021/acsinfecdis.9b00162. Epub 2019 Dec 11. ACS Infect Dis. 2020. PMID: 31775512 Free PMC article.

3

Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria.

Wallace MJ, Dharuman S, Fernando DM, Reeve SM, Gee CT, Yao J, Griffith EC, Phelps GA, Wright WC, Elmore JM, Lee RB, Chen T, Lee RE. Wallace MJ, et al. Among authors: gee ct. ACS Infect Dis. 2020 Mar 13;6(3):467-478. doi: 10.1021/acsinfecdis.9b00406. Epub 2020 Jan 13. ACS Infect Dis. 2020. PMID: 31887254 Free PMC article.

4

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.

Yang SW, Huang X, Lin W, Min J, Miller DJ, Mayasundari A, Rodrigues P, Griffith EC, Gee CT, Li L, Li W, Lee RE, Rankovic Z, Chen T, Potts PR. Yang SW, et al. Among authors: gee ct. Nat Commun. 2020 Oct 1;11(1):4931. doi: 10.1038/s41467-020-18708-x. Nat Commun. 2020. PMID: 33004795 Free PMC article.

5

A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes.

Cui H, Divakaran A, Hoell ZJ, Ellingson MO, Scholtz CR, Zahid H, Johnson JA, Griffith EC, Gee CT, Lee AL, Khanal S, Shi K, Aihara H, Shah VH, Lee RE, Harki DA, Pomerantz WCK. Cui H, et al. Among authors: gee ct. J Med Chem. 2022 Feb 10;65(3):2342-2360. doi: 10.1021/acs.jmedchem.1c01779. Epub 2022 Jan 10. J Med Chem. 2022. PMID: 35007061 Free PMC article.

6

Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors.

Buchholz CR, Sneddon MS, McPherson JE, Das S, Gee CT, Grillo MJ, Chai SC, Lee RE, Chen T, Harki DA, Shelat AA, Pomerantz WCK. Buchholz CR, et al. Among authors: gee ct. ACS Med Chem Lett. 2023 Oct 3;14(10):1441-1447. doi: 10.1021/acsmedchemlett.3c00343. eCollection 2023 Oct 12. ACS Med Chem Lett. 2023. PMID: 37849548

7

Fragment screening and druggability assessment for the CBP/p300 KIX domain through protein-observed 19F NMR spectroscopy.

Gee CT, Koleski EJ, Pomerantz WC. Gee CT, et al. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3735-9. doi: 10.1002/anie.201411658. Epub 2015 Feb 4. Angew Chem Int Ed Engl. 2015. PMID: 25651535 Free PMC article.

8

Protein-observed (19)F-NMR for fragment screening, affinity quantification and druggability assessment.

Gee CT, Arntson KE, Urick AK, Mishra NK, Hawk LM, Wisniewski AJ, Pomerantz WC. Gee CT, et al. Nat Protoc. 2016 Aug;11(8):1414-27. doi: 10.1038/nprot.2016.079. Epub 2016 Jul 14. Nat Protoc. 2016. PMID: 27414758 Free PMC article.

9

Paramagnetic relaxation enhancement for protein-observed ¹⁹F NMR as an enabling approach for efficient fragment screening.

Hawk LML, Gee CT, Urick AK, Hu H, Pomerantz WCK. Hawk LML, et al. Among authors: gee ct. RSC Adv. 2016;6(98):95715-95721. doi: 10.1039/C6RA21226C. Epub 2016 Sep 29. RSC Adv. 2016. PMID: 28496971 Free PMC article.

10

Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles.

Lee AL, Gee CT, Weegman BP, Einstein SA, Juelfs AR, Ring HL, Hurley KR, Egger SM, Swindlehurst G, Garwood M, Pomerantz WCK, Haynes CL. Lee AL, et al. Among authors: gee ct. ACS Nano. 2017 Jun 27;11(6):5623-5632. doi: 10.1021/acsnano.7b01006. Epub 2017 May 22. ACS Nano. 2017. PMID: 28505422 Free PMC article.

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