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The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates.
Camino JD, Gracia P, Chen SW, Sot J, de la Arada I, Sebastián V, Arrondo JLR, Goñi FM, Dobson CM, Cremades N. Camino JD, et al. Among authors: de la arada i. Chem Sci. 2020 Oct 15;11(43):11902-11914. doi: 10.1039/d0sc05297c. eCollection 2020 Nov 21. Chem Sci. 2020. PMID: 33520152 Free PMC article.
Deletion of a single helix from the transmembrane domain causes large changes in membrane insertion properties and secondary structure of the bacterial conjugation protein TrwB.
Vecino AJ, Segura Rde L, de la Arada I, de la Cruz F, Goñi FM, Arrondo JL, Alkorta I. Vecino AJ, et al. Among authors: de la cruz f, de la arada i. Biochim Biophys Acta. 2012 Dec;1818(12):3158-66. doi: 10.1016/j.bbamem.2012.08.015. Epub 2012 Aug 25. Biochim Biophys Acta. 2012. PMID: 22940106 Free article.
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