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The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability.
Cell Rep. 2021 Dec 7;37(10):110080. doi: 10.1016/j.celrep.2021.110080.
Cell Rep. 2021.
PMID: 34879279
Free PMC article.
p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation.
Kilgas S, Singh AN, Paillas S, Then CK, Torrecilla I, Nicholson J, Browning L, Vendrell I, Konietzny R, Kessler BM, Kiltie AE, Ramadan K.
Kilgas S, et al.
Cell Rep. 2021 May 25;35(8):109153. doi: 10.1016/j.celrep.2021.109153.
Cell Rep. 2021.
PMID: 34038735
Free PMC article.
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Immunofluorescence microscopy-based detection of ssDNA foci by BrdU in mammalian cells.
Kilgas S, Kiltie AE, Ramadan K.
Kilgas S, et al.
STAR Protoc. 2021 Nov 25;2(4):100978. doi: 10.1016/j.xpro.2021.100978. eCollection 2021 Dec 17.
STAR Protoc. 2021.
PMID: 34888531
Free PMC article.
Item in Clipboard
The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.
Singh AN, Oehler J, Torrecilla I, Kilgas S, Li S, Vaz B, Guérillon C, Fielden J, Hernandez-Carralero E, Cabrera E, Tullis ID, Meerang M, Barber PR, Freire R, Parsons J, Vojnovic B, Kiltie AE, Mailand N, Ramadan K.
Singh AN, et al. Among authors: kilgas s.
EMBO J. 2019 Oct 4;38(21):e102361. doi: 10.15252/embj.2019102361. Epub 2019 Oct 15.
EMBO J. 2019.
PMID: 31613024
Free PMC article.
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The Histone Deacetylase Inhibitor Romidepsin Spares Normal Tissues While Acting as an Effective Radiosensitizer in Bladder Tumors in Vivo.
Paillas S, Then CK, Kilgas S, Ruan JL, Thompson J, Elliott A, Smart S, Kiltie AE.
Paillas S, et al. Among authors: kilgas s.
Int J Radiat Oncol Biol Phys. 2020 May 1;107(1):212-221. doi: 10.1016/j.ijrobp.2020.01.015. Epub 2020 Jan 25.
Int J Radiat Oncol Biol Phys. 2020.
PMID: 31987970
Free PMC article.
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Inhibitors of the ATPase p97/VCP: From basic research to clinical applications.
Kilgas S, Ramadan K.
Kilgas S, et al.
Cell Chem Biol. 2023 Jan 19;30(1):3-21. doi: 10.1016/j.chembiol.2022.12.007. Epub 2023 Jan 13.
Cell Chem Biol. 2023.
PMID: 36640759
Free article.
Review.
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The Role of Extracellular Adenosine Triphosphate in Ischemic Organ Injury.
Zhao H, Kilgas S, Alam A, Eguchi S, Ma D.
Zhao H, et al. Among authors: kilgas s.
Crit Care Med. 2016 May;44(5):1000-12. doi: 10.1097/CCM.0000000000001603.
Crit Care Med. 2016.
PMID: 26825859
Review.
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