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Identifying the temporal electrophysiological and molecular changes that contribute to TSC-associated epileptogenesis.
JCI Insight. 2021 Dec 8;6(23):e150120. doi: 10.1172/jci.insight.150120.
JCI Insight. 2021.
PMID: 34877936
Free PMC article.
Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model.
Koene LMC, van Grondelle SE, Proietti Onori M, Wallaard I, Kooijman NHRM, van Oort A, Schreiber J, Elgersma Y.
Koene LMC, et al.
Ann Clin Transl Neurol. 2019 Jul;6(7):1273-1291. doi: 10.1002/acn3.50829. Epub 2019 Jun 24.
Ann Clin Transl Neurol. 2019.
PMID: 31353861
Free PMC article.
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RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.
Proietti Onori M, Koene LMC, Schäfer CB, Nellist M, de Brito van Velze M, Gao Z, Elgersma Y, van Woerden GM.
Proietti Onori M, et al. Among authors: koene lmc.
PLoS Biol. 2021 May 26;19(5):e3001279. doi: 10.1371/journal.pbio.3001279. eCollection 2021 May.
PLoS Biol. 2021.
PMID: 34038402
Free PMC article.
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Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome.
Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, Williams M, Heussler H, de Vrij FMS, Mientjes EJ, van Woerden GM, Kushner SA, Distel B, Elgersma Y.
Avagliano Trezza R, et al. Among authors: koene lmc.
Nat Neurosci. 2019 Aug;22(8):1235-1247. doi: 10.1038/s41593-019-0425-0. Epub 2019 Jun 24.
Nat Neurosci. 2019.
PMID: 31235931
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Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3.
Gutierrez-Castellanos N, Da Silva-Matos CM, Zhou K, Canto CB, Renner MC, Koene LMC, Ozyildirim O, Sprengel R, Kessels HW, De Zeeuw CI.
Gutierrez-Castellanos N, et al. Among authors: koene lmc.
Neuron. 2017 Jan 18;93(2):409-424. doi: 10.1016/j.neuron.2016.11.046.
Neuron. 2017.
PMID: 28103481
Free PMC article.
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