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Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood.
Kariotis S, Jammeh E, Swietlik EM, Pickworth JA, Rhodes CJ, Otero P, Wharton J, Iremonger J, Dunning MJ, Pandya D, Mascarenhas TS, Errington N, Thompson AAR, Romanoski CE, Rischard F, Garcia JGN, Yuan JX, An TS, Desai AA, Coghlan G, Lordan J, Corris PA, Howard LS, Condliffe R, Kiely DG, Church C, Pepke-Zaba J, Toshner M, Wort S, Gräf S, Morrell NW, Wilkins MR, Lawrie A, Wang D; UK National PAH Cohort Study Consortium. Kariotis S, et al. Among authors: garcia jgn. Nat Commun. 2021 Dec 7;12(1):7104. doi: 10.1038/s41467-021-27326-0. Nat Commun. 2021. PMID: 34876579 Free PMC article.
Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.
Sun X, Kellner M, Desai AA, Wang T, Lu Q, Kangath A, Qu N, Klinger C, Fratz S, Yuan JX, Jacobson JR, Garcia JG, Rafikov R, Fineman JR, Black SM. Sun X, et al. Am J Respir Cell Mol Biol. 2016 Aug;55(2):275-87. doi: 10.1165/rcmb.2015-0185OC. Am J Respir Cell Mol Biol. 2016. PMID: 26959555 Free PMC article.
Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension.
Tang H, Yamamura A, Yamamura H, Song S, Fraidenburg DR, Chen J, Gu Y, Pohl NM, Zhou T, Jiménez-Pérez L, Ayon RJ, Desai AA, Goltzman D, Rischard F, Khalpey Z, Black SM, Garcia JG, Makino A, Yuan JX. Tang H, et al. Am J Physiol Lung Cell Mol Physiol. 2016 May 1;310(9):L846-59. doi: 10.1152/ajplung.00050.2016. Epub 2016 Mar 11. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26968768 Free PMC article.
Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.
Song S, Ayon RJ, Yamamura A, Yamamura H, Dash S, Babicheva A, Tang H, Sun X, Cordery AG, Khalpey Z, Black SM, Desai AA, Rischard F, McDermott KM, Garcia JG, Makino A, Yuan JX. Song S, et al. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 1;312(3):L309-L325. doi: 10.1152/ajplung.00357.2016. Epub 2016 Dec 15. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 27979859 Free PMC article.
Association of circulating transcriptomic profiles with mortality in sickle cell disease.
Desai AA, Lei Z, Bahroos N, Maienschein-Cline M, Saraf SL, Zhang X, Shah BN, Nouraie SM, Abbasi T, Patel AR, Lang RM, Lussier Y, Garcia JGN, Gordeuk VR, Machado RF. Desai AA, et al. Among authors: garcia jgn. Blood. 2017 Jun 1;129(22):3009-3016. doi: 10.1182/blood-2016-11-752279. Epub 2017 Apr 3. Blood. 2017. PMID: 28373264 Free PMC article.
467 results