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Ultrapotent chemogenetics for research and potential clinical applications.
Magnus CJ, Lee PH, Bonaventura J, Zemla R, Gomez JL, Ramirez MH, Hu X, Galvan A, Basu J, Michaelides M, Sternson SM. Magnus CJ, et al. Among authors: michaelides m. Science. 2019 Apr 12;364(6436):eaav5282. doi: 10.1126/science.aav5282. Epub 2019 Mar 14. Science. 2019. PMID: 30872534 Free PMC article.
Evidence in primates supporting the use of chemogenetics for the treatment of human refractory neuropsychiatric disorders.
Roseboom PH, Mueller SAL, Oler JA, Fox AS, Riedel MK, Elam VR, Olsen ME, Gomez JL, Boehm MA, DiFilippo AH, Christian BT, Michaelides M, Kalin NH. Roseboom PH, et al. Among authors: michaelides m. Mol Ther. 2021 Dec 1;29(12):3484-3497. doi: 10.1016/j.ymthe.2021.04.021. Epub 2021 Apr 23. Mol Ther. 2021. PMID: 33895327 Free PMC article.
Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.
Gomez JL, Bonaventura J, Lesniak W, Mathews WB, Sysa-Shah P, Rodriguez LA, Ellis RJ, Richie CT, Harvey BK, Dannals RF, Pomper MG, Bonci A, Michaelides M. Gomez JL, et al. Among authors: michaelides m. Science. 2017 Aug 4;357(6350):503-507. doi: 10.1126/science.aan2475. Science. 2017. PMID: 28774929 Free PMC article.
High-potency ligands for DREADD imaging and activation in rodents and monkeys.
Bonaventura J, Eldridge MAG, Hu F, Gomez JL, Sanchez-Soto M, Abramyan AM, Lam S, Boehm MA, Ruiz C, Farrell MR, Moreno A, Galal Faress IM, Andersen N, Lin JY, Moaddel R, Morris PJ, Shi L, Sibley DR, Mahler SV, Nabavi S, Pomper MG, Bonci A, Horti AG, Richmond BJ, Michaelides M. Bonaventura J, et al. Among authors: michaelides m. Nat Commun. 2019 Oct 11;10(1):4627. doi: 10.1038/s41467-019-12236-z. Nat Commun. 2019. PMID: 31604917 Free PMC article.
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability.
Bonaventura J, Lam S, Carlton M, Boehm MA, Gomez JL, Solís O, Sánchez-Soto M, Morris PJ, Fredriksson I, Thomas CJ, Sibley DR, Shaham Y, Zarate CA Jr, Michaelides M. Bonaventura J, et al. Among authors: michaelides m. Mol Psychiatry. 2021 Nov;26(11):6704-6722. doi: 10.1038/s41380-021-01093-2. Epub 2021 Apr 15. Mol Psychiatry. 2021. PMID: 33859356 Free PMC article.
Time will tell. Reply to "Comments to pharmacological and behavioral divergence of ketamine enantiomers by Jordi Bonaventura et al." by Chen et al.
Bonaventura J, Lam S, Carlton M, Boehm M, Gomez JL, Solís O, Sánchez-Soto M, Morris PJ, Fredriksson I, Thomas CJ, Sibley DR, Shaham Y, Zarate CA Jr, Michaelides M. Bonaventura J, et al. Among authors: michaelides m. Mol Psychiatry. 2022 Apr;27(4):1863-1865. doi: 10.1038/s41380-022-01480-3. Epub 2022 Feb 22. Mol Psychiatry. 2022. PMID: 35194167 Free PMC article. No abstract available.
The show must go on. Reply to "Distinct functions of S-ketamine and R-ketamine in mediating biobehavioral processes of drug dependency: comments on Bonaventura et al" by Insop Shim.
Bonaventura J, Lam S, Carlton M, Boehm M, Gomez JL, Solís O, Sánchez-Soto M, Morris PJ, Fredriksson I, Thomas CJ, Sibley DR, Shaham Y, Zarate CA Jr, Michaelides M. Bonaventura J, et al. Among authors: michaelides m. Mol Psychiatry. 2023 Dec;28(12):4941-4942. doi: 10.1038/s41380-022-01666-9. Epub 2022 Jun 22. Mol Psychiatry. 2023. PMID: 35732692 No abstract available.
Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search.
Bonaventura J, Gomez JL, Carlton ML, Lam S, Sanchez-Soto M, Morris PJ, Moaddel R, Kang HJ, Zanos P, Gould TD, Thomas CJ, Sibley DR, Zarate CA Jr, Michaelides M. Bonaventura J, et al. Among authors: michaelides m. Mol Psychiatry. 2022 Oct;27(10):4144-4156. doi: 10.1038/s41380-022-01673-w. Epub 2022 Jun 29. Mol Psychiatry. 2022. PMID: 35768639 Free PMC article.
666 results