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Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug.
Alors-Perez E, Blázquez-Encinas R, Alcalá S, Viyuela-García C, Pedraza-Arevalo S, Herrero-Aguayo V, Jiménez-Vacas JM, Mafficini A, Sánchez-Frías ME, Cano MT, Abollo-Jiménez F, Marín-Sanz JA, Cabezas-Sainz P, Lawlor RT, Luchini C, Sánchez L, Sánchez-Hidalgo JM, Ventura S, Martin-Hijano L, Gahete MD, Scarpa A, Arjona-Sánchez Á, Ibáñez-Costa A, Sainz B Jr, Luque RM, Castaño JP. Alors-Perez E, et al. Among authors: sanchez l, sanchez frias me, sanchez hidalgo jm. J Exp Clin Cancer Res. 2021 Dec 2;40(1):382. doi: 10.1186/s13046-021-02153-9. J Exp Clin Cancer Res. 2021. PMID: 34857016 Free PMC article.
"A Zebra in the Water": Inspiring Science in Spain.
Guerra-Varela J, Cabezas-Sainz P, Yebra-Pimentel E, Gutiérrez-Lovera C, Cedrón VP, Otero Obarrio MA, Sciara AA, Rodríguez N, Araujo J, Millán A, Sánchez L. Guerra-Varela J, et al. Among authors: sanchez l. Zebrafish. 2016 Aug;13(4):241-7. doi: 10.1089/zeb.2015.1178. Epub 2016 May 3. Zebrafish. 2016. PMID: 27140317
Circulating Tumor Cells Characterization Revealed TIMP1 as a Potential Therapeutic Target in Ovarian Cancer.
Abreu M, Cabezas-Sainz P, Alonso-Alconada L, Ferreirós A, Mondelo-Macía P, Lago-Lestón RM, Abalo A, Díaz E, Palacios-Zambrano S, Rojo-Sebastian A, López-López R, Sánchez L, Moreno-Bueno G, Muinelo-Romay L. Abreu M, et al. Among authors: sanchez l. Cells. 2020 May 14;9(5):1218. doi: 10.3390/cells9051218. Cells. 2020. PMID: 32423054 Free PMC article.
Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells.
Valle S, Alcalá S, Martin-Hijano L, Cabezas-Sáinz P, Navarro D, Muñoz ER, Yuste L, Tiwary K, Walter K, Ruiz-Cañas L, Alonso-Nocelo M, Rubiolo JA, González-Arnay E, Heeschen C, Garcia-Bermejo L, Hermann PC, Sánchez L, Sancho P, Fernández-Moreno MÁ, Sainz B Jr. Valle S, et al. Among authors: sanchez l. Nat Commun. 2020 Oct 16;11(1):5265. doi: 10.1038/s41467-020-18954-z. Nat Commun. 2020. PMID: 33067432 Free PMC article.
2,258 results