Monahan JB - Search Results

1

The MK2/Hsp27 axis is a major survival mechanism for pancreatic ductal adenocarcinoma under genotoxic stress.

Grierson PM, Dodhiawala PB, Cheng Y, Chen TH, Khawar IA, Wei Q, Zhang D, Li L, Herndon J, Monahan JB, Ruzinova MB, Lim KH. Grierson PM, et al. Among authors: monahan jb. Sci Transl Med. 2021 Dec;13(622):eabb5445. doi: 10.1126/scitranslmed.abb5445. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851698 Free PMC article.

2

Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.

Wang C, Hockerman S, Jacobsen EJ, Alippe Y, Selness SR, Hope HR, Hirsch JL, Mnich SJ, Saabye MJ, Hood WF, Bonar SL, Abu-Amer Y, Haimovich A, Hoffman HM, Monahan JB, Mbalaviele G. Wang C, et al. Among authors: monahan jb. J Exp Med. 2018 May 7;215(5):1315-1325. doi: 10.1084/jem.20172063. Epub 2018 Mar 16. J Exp Med. 2018. PMID: 29549113 Free PMC article.

3

Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss.

Murali B, Ren Q, Luo X, Faget DV, Wang C, Johnson RM, Gruosso T, Flanagan KC, Fu Y, Leahy K, Alspach E, Su X, Ross MH, Burnette B, Weilbaecher KN, Park M, Mbalaviele G, Monahan JB, Stewart SA. Murali B, et al. Among authors: monahan jb. Cancer Res. 2018 Oct 1;78(19):5618-5630. doi: 10.1158/0008-5472.CAN-18-0234. Epub 2018 Aug 9. Cancer Res. 2018. PMID: 30093561 Free PMC article.

4

Substrate-based kinase activity inference identifies MK2 as driver of colitis.

Strasser SD, Ghazi PC, Starchenko A, Boukhali M, Edwards A, Suarez-Lopez L, Lyons J, Changelian PS, Monahan JB, Jacobsen J, Brubaker DK, Joughin BA, Yaffe MB, Haas W, Lauffenburger DA, Haigis KM. Strasser SD, et al. Among authors: monahan jb. Integr Biol (Camb). 2019 Nov 26;11(7):301-314. doi: 10.1093/intbio/zyz025. Integr Biol (Camb). 2019. PMID: 31617572 Free PMC article.

5

p38MAPKα Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy.

Faget DV, Luo X, Inkman MJ, Ren Q, Su X, Ding K, Waters MR, Raut GK, Pandey G, Dodhiawala PB, Ramalho-Oliveira R, Ye J, Cole T, Murali B, Zheleznyak A, Shokeen M, Weiss KR, Monahan JB, DeSelm CJ, Lee AV, Oesterreich S, Weilbaecher KN, Zhang J, DeNardo DG, Stewart SA. Faget DV, et al. Among authors: monahan jb. Cancer Discov. 2023 Jun 2;13(6):1454-1477. doi: 10.1158/2159-8290.CD-22-0907. Cancer Discov. 2023. PMID: 36883955 Free PMC article.

6

Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.

Morris DL, O'Neil SP, Devraj RV, Portanova JP, Gilles RW, Gross CJ, Curtiss SW, Komocsar WJ, Garner DS, Happa FA, Kraus LJ, Nikula KJ, Monahan JB, Selness SR, Galluppi GR, Shevlin KM, Kramer JA, Walker JK, Messing DM, Anderson DR, Mourey RJ, Whiteley LO, Daniels JS, Yang JZ, Rowlands PC, Alden CL, Davis JW 2nd, Sagartz JE. Morris DL, et al. Among authors: monahan jb. Toxicol Pathol. 2010 Jun;38(4):606-18. doi: 10.1177/0192623310367807. Epub 2010 May 6. Toxicol Pathol. 2010. PMID: 20448081

7

Therapy-Induced Senescence Drives Bone Loss.

Yao Z, Murali B, Ren Q, Luo X, Faget DV, Cole T, Ricci B, Thotala D, Monahan J, van Deursen JM, Baker D, Faccio R, Schwarz JK, Stewart SA. Yao Z, et al. Cancer Res. 2020 Mar 1;80(5):1171-1182. doi: 10.1158/0008-5472.CAN-19-2348. Epub 2020 Jan 13. Cancer Res. 2020. PMID: 31932453 Free PMC article.

8

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study.

Gordon D, Hellriegel ET, Hope HR, Burt D, Monahan JB. Gordon D, et al. Among authors: monahan jb. Clin Pharmacol. 2021 Jun 10;13:123-134. doi: 10.2147/CPAA.S305308. eCollection 2021. Clin Pharmacol. 2021. PMID: 34140814 Free PMC article.

9

Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.

Xiao J, Wang C, Yao JC, Alippe Y, Yang T, Kress D, Sun K, Kostecki KL, Monahan JB, Veis DJ, Abu-Amer Y, Link DC, Mbalaviele G. Xiao J, et al. Among authors: monahan jb. PLoS Biol. 2020 Aug 6;18(8):e3000807. doi: 10.1371/journal.pbio.3000807. eCollection 2020 Aug. PLoS Biol. 2020. PMID: 32760056 Free PMC article.

10

Examination of the kinetic mechanism of mitogen-activated protein kinase activated protein kinase-2.

Schindler JF, Godbey A, Hood WF, Bolten SL, Broadus RM, Kasten TP, Cassely AJ, Hirsch JL, Merwood MA, Nagy MA, Fok KF, Saabye MJ, Morgan HM, Compton RP, Mourey RJ, Wittwer AJ, Monahan JB. Schindler JF, et al. Among authors: monahan jb. Biochim Biophys Acta. 2002 Jul 29;1598(1-2):88-97. doi: 10.1016/s0167-4838(02)00340-0. Biochim Biophys Acta. 2002. PMID: 12147348

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