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Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors.
Tran W, Kusay AS, Hawkins PME, Cheung CY, Nagalingam G, Pujari V, Ford DJ, Stoye A, Ochoa JL, Audette RE, Hortle E, Oehlers SH, Charman SA, Linington RG, Rubin EJ, Dowson CG, Roper DI, Crick DC, Balle T, Cook GM, Britton WJ, Payne RJ. Tran W, et al. Among authors: audette re. J Med Chem. 2021 Dec 9;64(23):17326-17345. doi: 10.1021/acs.jmedchem.1c01407. Epub 2021 Nov 30. J Med Chem. 2021. PMID: 34845906
Protective efficacy of an attenuated Mtb ΔLprG vaccine in mice.
Martinot AJ, Blass E, Yu J, Aid M, Mahrokhian SH, Cohen SB, Plumlee CR, Larocca RA, Siddiqi N, Wakabayashi S, Gardner M, Audette R, Devorak A, Urdahl KB, Rubin EJ, Barouch DH. Martinot AJ, et al. PLoS Pathog. 2020 Dec 14;16(12):e1009096. doi: 10.1371/journal.ppat.1009096. eCollection 2020 Dec. PLoS Pathog. 2020. PMID: 33315936 Free PMC article.
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT. Johnson EO, et al. Among authors: audette re. Nature. 2019 Jul;571(7763):72-78. doi: 10.1038/s41586-019-1315-z. Epub 2019 Jun 19. Nature. 2019. PMID: 31217586